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Opioid-induced Hibernation Protects Against Stroke In Rats

Date:
June 19, 2009
Source:
BioMed Central
Summary:
Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers have shown that those animals put into the chemical slumber suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.
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Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers have shown that those animals put into the chemical fugue suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.

Cesar Borlongan, a neuroscientist at the University of South Florida Center for Aging and Brain Repair, in Tampa, FL, worked with a team of researchers from the National Institutes of Health, USA, to investigate the role of the opioid system in brain injury and protection. He said, "Studies in hibernating and active squirrels have shown that 'natural hibernation' has anti-ischemic effects. We've shown that a drug that induces hibernation can achieve similar results".

Borlongan and his colleagues dosed the rats with [D-ala2,D-leU5]enkephalin (DADLE), a drug from the same pharmaceutical family as morphine and heroin. They found that, after an experimental stroke, the pretreated animals performed better than control rats in a series of behavioral tests.

The researchers write, "DADLE prevented cell death processes and behavioral abnormalities. The observation that this substance, previously shown to induce hibernation, attenuated deficits inherent in cerebral ischemia provides a new pharmacological target for stroke therapy".


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The above post is reprinted from materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cesar V Borlongan, Teruo Hayashi, Peter R Oeltgen, Tsung-Ping Su and Yun Wang. Hibernation-like state induced by an opioid peptide protects against experimental stroke. BMC Biology, (in press) [link]

Cite This Page:

BioMed Central. "Opioid-induced Hibernation Protects Against Stroke In Rats." ScienceDaily. ScienceDaily, 19 June 2009. <www.sciencedaily.com/releases/2009/06/090616205512.htm>.
BioMed Central. (2009, June 19). Opioid-induced Hibernation Protects Against Stroke In Rats. ScienceDaily. Retrieved July 2, 2015 from www.sciencedaily.com/releases/2009/06/090616205512.htm
BioMed Central. "Opioid-induced Hibernation Protects Against Stroke In Rats." ScienceDaily. www.sciencedaily.com/releases/2009/06/090616205512.htm (accessed July 2, 2015).

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