Featured Research

from universities, journals, and other organizations

Opioid-induced Hibernation Protects Against Stroke In Rats

Date:
June 19, 2009
Source:
BioMed Central
Summary:
Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers have shown that those animals put into the chemical slumber suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.

Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers have shown that those animals put into the chemical fugue suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.

Cesar Borlongan, a neuroscientist at the University of South Florida Center for Aging and Brain Repair, in Tampa, FL, worked with a team of researchers from the National Institutes of Health, USA, to investigate the role of the opioid system in brain injury and protection. He said, "Studies in hibernating and active squirrels have shown that 'natural hibernation' has anti-ischemic effects. We've shown that a drug that induces hibernation can achieve similar results".

Borlongan and his colleagues dosed the rats with [D-ala2,D-leU5]enkephalin (DADLE), a drug from the same pharmaceutical family as morphine and heroin. They found that, after an experimental stroke, the pretreated animals performed better than control rats in a series of behavioral tests.

The researchers write, "DADLE prevented cell death processes and behavioral abnormalities. The observation that this substance, previously shown to induce hibernation, attenuated deficits inherent in cerebral ischemia provides a new pharmacological target for stroke therapy".


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cesar V Borlongan, Teruo Hayashi, Peter R Oeltgen, Tsung-Ping Su and Yun Wang. Hibernation-like state induced by an opioid peptide protects against experimental stroke. BMC Biology, (in press) [link]

Cite This Page:

BioMed Central. "Opioid-induced Hibernation Protects Against Stroke In Rats." ScienceDaily. ScienceDaily, 19 June 2009. <www.sciencedaily.com/releases/2009/06/090616205512.htm>.
BioMed Central. (2009, June 19). Opioid-induced Hibernation Protects Against Stroke In Rats. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2009/06/090616205512.htm
BioMed Central. "Opioid-induced Hibernation Protects Against Stroke In Rats." ScienceDaily. www.sciencedaily.com/releases/2009/06/090616205512.htm (accessed July 29, 2014).

Share This




More Mind & Brain News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com
University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins