Featured Research

from universities, journals, and other organizations

Opioid-induced Hibernation Protects Against Stroke In Rats

Date:
June 19, 2009
Source:
BioMed Central
Summary:
Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers have shown that those animals put into the chemical slumber suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.

Using an opioid drug to induce a hibernatory state in rats reduces the damage caused by an artificial stroke. Researchers have shown that those animals put into the chemical fugue suffered less behavioral dysfunctions after a period of cerebral artery blockage than control rats.

Related Articles


Cesar Borlongan, a neuroscientist at the University of South Florida Center for Aging and Brain Repair, in Tampa, FL, worked with a team of researchers from the National Institutes of Health, USA, to investigate the role of the opioid system in brain injury and protection. He said, "Studies in hibernating and active squirrels have shown that 'natural hibernation' has anti-ischemic effects. We've shown that a drug that induces hibernation can achieve similar results".

Borlongan and his colleagues dosed the rats with [D-ala2,D-leU5]enkephalin (DADLE), a drug from the same pharmaceutical family as morphine and heroin. They found that, after an experimental stroke, the pretreated animals performed better than control rats in a series of behavioral tests.

The researchers write, "DADLE prevented cell death processes and behavioral abnormalities. The observation that this substance, previously shown to induce hibernation, attenuated deficits inherent in cerebral ischemia provides a new pharmacological target for stroke therapy".


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cesar V Borlongan, Teruo Hayashi, Peter R Oeltgen, Tsung-Ping Su and Yun Wang. Hibernation-like state induced by an opioid peptide protects against experimental stroke. BMC Biology, (in press) [link]

Cite This Page:

BioMed Central. "Opioid-induced Hibernation Protects Against Stroke In Rats." ScienceDaily. ScienceDaily, 19 June 2009. <www.sciencedaily.com/releases/2009/06/090616205512.htm>.
BioMed Central. (2009, June 19). Opioid-induced Hibernation Protects Against Stroke In Rats. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2009/06/090616205512.htm
BioMed Central. "Opioid-induced Hibernation Protects Against Stroke In Rats." ScienceDaily. www.sciencedaily.com/releases/2009/06/090616205512.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com
Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Smartphone Use Changing Our Brain and Thumb Interaction, Say Researchers

Reuters - Innovations Video Online (Mar. 25, 2015) European researchers say our smartphone use offers scientists an ideal testing ground for human brain plasticity. Dr Ako Ghosh&apos;s team discovered that the brains and thumbs of smartphone users interact differently from those who use old-fashioned handsets. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Many Don't Know They Have Alzheimer's, But Their Doctors Do

Many Don't Know They Have Alzheimer's, But Their Doctors Do

Newsy (Mar. 24, 2015) According to a new study by the Alzheimer&apos;s Association, more than half of those who have the degenerative brain disease aren&apos;t told by their doctors. Video provided by Newsy
Powered by NewsLook.com
A Quick 45-Minute Nap Can Improve Your Memory

A Quick 45-Minute Nap Can Improve Your Memory

Newsy (Mar. 23, 2015) Researchers found those who napped for 45 minutes to an hour before being tested on information recalled it five times better than those who didn&apos;t. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins