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Risk Of Liver Cancer In Women With Hepatitis B Virus Infection Varies With Number Of Pregnancies

Date:
July 3, 2009
Source:
Journal of the National Cancer Institute
Summary:
Risk for hepatocellular carcinoma, a primary malignancy of the liver, was statistically significantly higher among women with hepatitis B virus (HBV) infection than among women without the virus, according to a new study.
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Risk for hepatocellular carcinoma, a primary malignancy of the liver, was statistically significantly higher among women with hepatitis B virus (HBV) infection than among women without the virus, according to a new study.

Because hepatocellular carcinoma mostly occurs in men, few women have been included in long-term studies of the association between HBV infection and this carcinoma.

In this study, Chien-Jen Chen, Sc.D., of the Genomics Research Center in Taipei, Taiwan, and colleagues used a nationwide cohort of more than 1.5 million pregnant Taiwanese women tested from 1983 to 2000 to study relationships of HBV infection and parity with hepatocellular risk.

The researchers found that risk for hepatocellular carcinoma during follow-up was statistically significantly higher among pregnant women who had chronic, active, or persistent HBV infections (and even in those who had seroclearance for hepatitis B surface antigen during follow-up) than among women who were not carriers of hepatitis B surface antigen at study entry.

The more children a woman had, the lower her risk appeared to be. This inverse relationship between parity and the risk of hepatocellular carcinoma was statistically significant. "Underlying biological mechanisms responsible for this…merit further investigation," the authors write.

This research was published in the Journal of the National Cancer Institute on June 17, 2009.


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The above post is reprinted from materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


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Journal of the National Cancer Institute. "Risk Of Liver Cancer In Women With Hepatitis B Virus Infection Varies With Number Of Pregnancies." ScienceDaily. ScienceDaily, 3 July 2009. <www.sciencedaily.com/releases/2009/06/090617161504.htm>.
Journal of the National Cancer Institute. (2009, July 3). Risk Of Liver Cancer In Women With Hepatitis B Virus Infection Varies With Number Of Pregnancies. ScienceDaily. Retrieved July 27, 2015 from www.sciencedaily.com/releases/2009/06/090617161504.htm
Journal of the National Cancer Institute. "Risk Of Liver Cancer In Women With Hepatitis B Virus Infection Varies With Number Of Pregnancies." ScienceDaily. www.sciencedaily.com/releases/2009/06/090617161504.htm (accessed July 27, 2015).

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