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Psychotherapy Of Depression Changes Biological Parameters?

Date:
July 6, 2009
Source:
Journal of Psychotherapy and Psychosomatics
Summary:
Investigators have demonstrated that the early increase in phosphorylated CREB (pCREB) is related to treatment response and does not depend on pharmacological interventions or brain-derived neurotrophic factor (BDNF) plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy.

A group of German investigators demonstrated that the early increase in phosphorylated CREB (pCREB) is related to treatment response and does not depend on pharmacological interventions or brain-derived neurotrophic factor (BDNF) plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy.

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The cyclic adenosine monophosphate response element-binding proteins (CREB) and their interaction with brain-derived neurotrophic factor (BDNF) are essential elements in signal transduction pathways important for cellular resilience and neuroplasticity. They play a decisive role in the concept of altered neuroplasticity in major depression.

The Authors of thisstudy have previously demonstrated that the increase in phosphorylated CREB (pCREB) in T lymphocytes is significantly associated with clinical improvement in patients treated with antidepressants. In the present study, they focused on patients treated only with psychotherapy to exclude direct pharmacological actions.

In addition to pCREB, they also measured the BDNF plasma levels. pCREB in T lymphocytes was determined by Western blot; the BDNF plasma levels with solid-phase ELISA. Psychopathology was evaluated with the Hamilton Rating Scale for Depression (HAMD).

Thirty patients meeting DSM-IV criteria for major depressive episodes (MDE) were recruited into this 6-week study. They received interpersonal psychotherapy (IPT) twice weekly. After 6 weeks of IPT, 17 patients responded (reduction of 50% of baseline HAMD); after 1 week of treatment pCREB increased significantly compared to the nonresponder group. Measurement of the BDNF plasma levels revealed no differences between the responder and nonresponder groups.

Furthermore, the correlations between BDNF plasma levels and pCREB were not significant. The early increase in pCREB is related to treatment response and does not depend on pharmacological interventions or BDNF plasma levels. For the first time, cellular biological markers could be associated with response to psychotherapy.


Story Source:

The above story is based on materials provided by Journal of Psychotherapy and Psychosomatics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Koch et al. Changes in CREB Phosphorylation and BDNF Plasma Levels during Psychotherapy of Depression. Psychotherapy and Psychosomatics, 2009; 78 (3): 187 DOI: 10.1159/000209350

Cite This Page:

Journal of Psychotherapy and Psychosomatics. "Psychotherapy Of Depression Changes Biological Parameters?." ScienceDaily. ScienceDaily, 6 July 2009. <www.sciencedaily.com/releases/2009/06/090623090154.htm>.
Journal of Psychotherapy and Psychosomatics. (2009, July 6). Psychotherapy Of Depression Changes Biological Parameters?. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2009/06/090623090154.htm
Journal of Psychotherapy and Psychosomatics. "Psychotherapy Of Depression Changes Biological Parameters?." ScienceDaily. www.sciencedaily.com/releases/2009/06/090623090154.htm (accessed November 1, 2014).

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