Featured Research

from universities, journals, and other organizations

3-D Protein Map To Aid Stroke And Cancer Research Drafted

Date:
July 9, 2009
Source:
University of Alabama at Birmingham
Summary:
Researchers have generated a computer map of the protein acid-sensing ion channel-1, or ASIC-1, an important neurological pathway. The map greatly simplifies the testing of drugs or compounds designed to protect neurons, regulate their molecular interactions or isolate brain tumors. The ASIC-1 work began with a toxin found only in the venom of the Trinidad chevron tarantula.

A new three-dimensional computer protein map is helping researchers at the University of Alabama at Birmingham (UAB) unravel the biological pathways that control brain-cell death after a stroke.

Related Articles


The new map will help identify new drug targets and test compounds to slow brain-cell death, halt brain cancer and improve pain control, the study authors said. The findings are published online in the Journal of Biological Chemistry.

Starting with known cell coordinates, biological structures and other data, UAB researchers focused on a protein called acid-sensing ion channel-1, or ASIC-1. This protein acts as a gateway on the surface of brain cells called neurons. The researchers generated a 3-D computer map of ASIC-1, which greatly simplifies the testing of any drug or compound designed to protect neurons, regulate their molecular interactions or isolate brain tumors.

"This protein ASIC-1 has a lot of little nooks and crevices where other molecules can sit and interact with the channel," said Yawar Qadri, a graduate student in the UAB Department of Physiology and Biophysics and the study's lead author. "With the map we've generated and the area we've described, researchers can fine-tune their ideas and tailor experimental compounds."

Dale Benos, Ph.D., chair of the Department of Physiology and Biophysics and a co-author on the study, said the ASIC-1 map is an invaluable tool in the ongoing search for new drugs that will specifically act on this biological pathway.

"The hope is that when a person has a stroke or they get diagnosed with a brain tumor, the patient can be given a drug that will keep his or her neurons alive and functioning longer, or we can keep cancer from migrating further," Benos said.

The study began with a toxin found only in the venom of the Trinidad chevron tarantula. In earlier laboratory research, this venom toxin proved capable of slowing neuronal death, inhibiting cancer growth and improving other biological disorders. UAB researchers wanted to simplify the search for non-venom agents that interact with ASIC-1 for positive results.

Qadri and his UAB colleagues generated the map of ASIC-1 with a software program called Modeller, developed by engineers at the University of California, San Francisco. The UAB ASIC-l map study includes validation work confirming its accuracy.


Story Source:

The above story is based on materials provided by University of Alabama at Birmingham. Note: Materials may be edited for content and length.


Cite This Page:

University of Alabama at Birmingham. "3-D Protein Map To Aid Stroke And Cancer Research Drafted." ScienceDaily. ScienceDaily, 9 July 2009. <www.sciencedaily.com/releases/2009/06/090625100353.htm>.
University of Alabama at Birmingham. (2009, July 9). 3-D Protein Map To Aid Stroke And Cancer Research Drafted. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/06/090625100353.htm
University of Alabama at Birmingham. "3-D Protein Map To Aid Stroke And Cancer Research Drafted." ScienceDaily. www.sciencedaily.com/releases/2009/06/090625100353.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins