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Understanding The Anticancer Effects Of Vitamin D3

Date:
July 7, 2009
Source:
Journal of Clinical Investigation
Summary:
The active form of vitamin D3 seems to have anticancer effects. New research has identified a major mechanism underlying these effects. Specifically, the protein cystatin D, which is induced by the active form of vitamin D3, has tumor suppressor activity that accounts for much of the anticancer effect of the active form of vitamin D3.
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The active form of vitamin D3 seems to have anticancer effects. To try and understand the mechanisms underlying these effects, researchers previously set out to identify genes whose expression in a human colon cancer cell line was altered by the active form of vitamin D3.

One gene identified in this previous study was CST5, which is responsible for making the protein cystatin D. Now, a team of researchers, at the Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Spain, and the Universidad de Oviedo, Spain, has studied this protein in detail and determined that it has tumor suppressor activity that likely accounts for some of the anticancer effects of the active form of vitamin D3.

The team, led by Alberto Muñoz and Carlos López-Otín, initially established that the active form of vitamin D3 directly activates the CST5 gene in human colon cancer cell lines, increasing levels of cystatin D protein. Functionally, cystatin D was shown to inhibit the growth of human colon cancer cells lines in vitro and when they were xenotransplanted into mice. As knocking down expression of cystatin D in human colon cancer cell lines rendered them unresponsive to the antiproliferative effects of the active form of vitamin D3, the authors conclude that CST5 is a candidate tumor suppressor gene and that it mediates a large proportion of the anticancer effects of the active form of vitamin D3. These data provide rationale for clinical trials examining the preventive and therapeutic potential of the active form of vitamin D3 in colon cancer.


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The above post is reprinted from materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. Journal of Clinical Investigation, July 6, 2009

Cite This Page:

Journal of Clinical Investigation. "Understanding The Anticancer Effects Of Vitamin D3." ScienceDaily. ScienceDaily, 7 July 2009. <www.sciencedaily.com/releases/2009/07/090706171500.htm>.
Journal of Clinical Investigation. (2009, July 7). Understanding The Anticancer Effects Of Vitamin D3. ScienceDaily. Retrieved July 2, 2015 from www.sciencedaily.com/releases/2009/07/090706171500.htm
Journal of Clinical Investigation. "Understanding The Anticancer Effects Of Vitamin D3." ScienceDaily. www.sciencedaily.com/releases/2009/07/090706171500.htm (accessed July 2, 2015).

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