Featured Research

from universities, journals, and other organizations

Continued Vigilance Against Drug-resistance Malaria Is Needed

Date:
August 29, 2009
Source:
Wiley-Blackwell
Summary:
Current combination malaria therapies recommended by the World Health Organization provide adequate treatment for mild malaria, according to a review of the evidence. However, selected trials had high failure rates for some combinations and evidence for the effectiveness of anti-malarial therapies is lacking in some vulnerable groups.

Current combination malaria therapies recommended by the World Health Organisation (WHO) provide adequate treatment for mild malaria, according to a Cochrane Systematic Review of the evidence. However, selected trials had high failure rates for some combinations and evidence for the effectiveness of anti-malarial therapies is lacking in some vulnerable groups.

Malaria kills more than a million people each year and accounts for more than a third of public health expenditure in some badly affected countries. Uncomplicated malaria is a mild version of the disease, but it can become serious and life threatening if left untreated. Resistance to the older antimalarials has led the WHO to recommend treatments combining an artemisinin-based drug with another longer-lasting drug to combat resistance.

The review included 50 trials of artemisinin-based combination therapies (ACTs). Overall, the four combinations studied were effective for treatment of the most common type of malarial parasite. The researchers conclude that the recently introduced dihydroartemisinin-piperaquine performed well compared to the ACTs in current use and offers another potential first-line therapy for the disease.

There were examples of treatment failure rates above 10% for all evaluated combinations. This is above the maximum allowable failure rate for a first line antimalarial as recommended by the WHO.

"Patterns of resistance change from place to place and over time, so these results have to be interpreted with some caution," says lead researcher David Sinclair of the Liverpool School of Tropical Medicine in Liverpool, UK. "Our findings emphasise the need for continued vigilance in the monitoring of malaria and the development of resistance to antimalarial drugs."

In addition, there were few studies focusing on the most at-risk groups, which are pregnant women and young infants. "The lack of evidence supporting the use of these drugs in pregnant women and infants represents a critical gap in our knowledge that must be addressed," says Sinclair.


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Cite This Page:

Wiley-Blackwell. "Continued Vigilance Against Drug-resistance Malaria Is Needed." ScienceDaily. ScienceDaily, 29 August 2009. <www.sciencedaily.com/releases/2009/07/090707201209.htm>.
Wiley-Blackwell. (2009, August 29). Continued Vigilance Against Drug-resistance Malaria Is Needed. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2009/07/090707201209.htm
Wiley-Blackwell. "Continued Vigilance Against Drug-resistance Malaria Is Needed." ScienceDaily. www.sciencedaily.com/releases/2009/07/090707201209.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins