Featured Research

from universities, journals, and other organizations

Light Shed On DNA Mechanisms

Date:
July 22, 2009
Source:
Georgia State University
Summary:
By manipulating individual atoms in DNA and forming unique molecules, a researcher hopes to open new avenues in research towards better understanding the mechanisms of DNA replication and transcription, and perhaps leading to new treatments for diseases.

By manipulating individual atoms in DNA and forming unique molecules, a Georgia State University researcher hopes to open new avenues in research towards better understanding the mechanisms of DNA replication and transcription, and perhaps leading to new treatments for diseases.

Related Articles


Chemistry and chemical biology Professor Zhen Huang and his lab were able for the first time, to manipulate groups of molecules, called methyl and phosphate groups, in DNA that has been altered to contain selenium in order to bring them close enough together to form hydrogen bonds.

Such interactions may reduce the energy needed for a process called DNA duplex separation, thereby playing a role in the unwinding of DNA, which must happen in order for the genetic code to be copied and transcribed during cell replication and transcription. The research also helps to explain how energy is used in the process, Huang said.

"Assume that you want to do something, like to move an object from downstairs to upstairs, or building a pyramid where heavy blocks have to be transported," Huang said. "You need lots of energy for these processes.

"If you need lots of energy, it will be a slow process or become inhibited because it consumes too much energy."

With DNA in humans, the genome is comprised of about 3 billion base pairs, which are part of DNA's "ladder" in the double helix which forms the code that causes certain genetic traits. If it takes a lot of energy to unwind DNA in order to duplicate, the process is slowed. On the other hand, if cellular dividing is too fast, DNA isn't copied properly with full length, which causes unhealthy cells to be formed.

New research directions may open from the study, which could also have practical implications, Huang said, such as better understanding how RNA, which is involved in protein synthesis, is transcribed and works.

If scientists know the shape and structure of DNA and RNA, scientists can design drugs to bind to the molecules in question — inhibiting the expression and progression of a disease, thus killing it off — whether it's cancer, HIV or any other viruses.

The research appears in the June 8, 2009 edition of Chemical & Engineering News and in the June 2009 edition of Organic Letters.


Story Source:

The above story is based on materials provided by Georgia State University. Note: Materials may be edited for content and length.


Cite This Page:

Georgia State University. "Light Shed On DNA Mechanisms." ScienceDaily. ScienceDaily, 22 July 2009. <www.sciencedaily.com/releases/2009/07/090717153955.htm>.
Georgia State University. (2009, July 22). Light Shed On DNA Mechanisms. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/07/090717153955.htm
Georgia State University. "Light Shed On DNA Mechanisms." ScienceDaily. www.sciencedaily.com/releases/2009/07/090717153955.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bionic Ants Could Be Tomorrow's Factory Workers

Bionic Ants Could Be Tomorrow's Factory Workers

Reuters - Innovations Video Online (Mar. 30, 2015) Industrious 3D printed bionic ants working together could toil in the factories of the future, says German technology company Festo. The robotic insects cooperate and coordinate their actions and movements to achieve a common aim. Amy Pollock reports. Video provided by Reuters
Powered by NewsLook.com
You Won't Be Driving Tesla's Mystery Product

You Won't Be Driving Tesla's Mystery Product

Newsy (Mar. 30, 2015) Tesla CEO Elon Musk announced a new product line will debut April 30, but it&apos;s not a car. Video provided by Newsy
Powered by NewsLook.com
Solar Impulse Departs Myanmar for China

Solar Impulse Departs Myanmar for China

AFP (Mar. 30, 2015) Solar Impulse 2 takes off from Myanmar&apos;s second biggest city of Mandalay and heads for China&apos;s Chongqing, the fifth flight of a landmark journey to circumnavigate the globe powered solely by the sun. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Internet Giants Drive Into the Electric Vehicle Space

Internet Giants Drive Into the Electric Vehicle Space

Reuters - Business Video Online (Mar. 30, 2015) Internet companies are looking to disrupt the auto industry with new smart e-vehicles, but widespread adoption in Asia may not be cured by new Chinese investments. Pamela Ambler reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins