Featured Research

from universities, journals, and other organizations

Mathematical Modeling Predicts Response To Herceptin

Date:
August 4, 2009
Source:
American Association for Cancer Research
Summary:
Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new article illustrates how the technique may answer questions about Herceptin resistance.

Cancer researchers are turning to mathematical models to help answer important clinical questions, and a new paper in Cancer Research, a journal of the American Association for Cancer Research, illustrates how the technique may answer questions about Herceptin resistance.

Sofia Merajver, M.D., Ph.D., scientific director of the Breast Oncology Program at the University of Michigan Comprehensive Cancer Center, and a senior editorial board member of Cancer Research, said the potential of mathematical oncology is nothing short of revolutionary. These landmark papers now have a potential forum in the Mathematical Oncology section of Cancer Research, whose wide readership will help the new results reach the clinic.

"Computational power has reached the point where models that could previously only be used to predict weather patterns, space travel or the effect of nuclear explosions can now be used in the clinic to estimate the impact of certain drugs," said Merajver.

The current paper, which was carried out at the Breakthrough Breast Cancer Research Unit Edinburgh and led by Dana Faratian, M.D., a clinical lecturer in pathology at the University of Edinburgh, examined the role of PTEN protein expression on resistance to Herceptin. PTEN is a protein that acts as a tumor suppressor gene.

"Herceptin has benefited thousands of women with HER2 positive breast cancer, but only a third to half of patients treated with this agent respond," said Faratian. "We need to know which patients will or won't respond to treatment and this research is a step towards realising that aim."

For the current study, Faratian and colleagues built a mathematical model that used 56 differential equations to analyze the change in concentrations of 56 separate biological entities including proteins and lipid second messengers.

Researchers worked with 122 breast cancers treated with Herceptin and found that quantitative PTEN protein expression was a key determinant of who would be resistant or sensitive to Herceptin.

Furthermore, using the mathematical modeling techniques, the absence of PTEN was more predictive than could be determined using standard multivariate or laboratory analysis.

"This paper is a major step forward because as revolutionary as Herceptin has been, there are many patients who fail. This helps us understand why and it would not have been possible without the new mathematical techniques," said Merajver.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Mathematical Modeling Predicts Response To Herceptin." ScienceDaily. ScienceDaily, 4 August 2009. <www.sciencedaily.com/releases/2009/07/090728132233.htm>.
American Association for Cancer Research. (2009, August 4). Mathematical Modeling Predicts Response To Herceptin. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2009/07/090728132233.htm
American Association for Cancer Research. "Mathematical Modeling Predicts Response To Herceptin." ScienceDaily. www.sciencedaily.com/releases/2009/07/090728132233.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins