Featured Research

from universities, journals, and other organizations

Nanotech Particles Affect Brain Development In Mice

Date:
July 30, 2009
Source:
BioMed Central
Summary:
Maternal exposure to nanoparticles of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in developing mice. Researchers found that mice whose mothers were injected with the nanoparticles while pregnant showed alteration in gene expression related to neurological dysfunction.

Two nine day old baby mice. Maternal exposure to nanoparticles of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in developing mice. Researchers found that mice whose mothers were injected with the nanoparticles while pregnant showed alteration in gene expression related to neurological dysfunction.
Credit: iStockphoto/Tamara Bauer

Maternal exposure to nanoparticles of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in developing mice. Researchers found that mice whose mothers were injected with the nanoparticles while pregnant showed alteration in gene expression related to neurological dysfunction.

Ken Takeda led a team of researchers from the Tokyo University of Science, Japan, who carried out the tests. He said, "Nanotechnology and the production of novel man-made nanoparticles are increasing worldwide. Titanium dioxide in its nanoparticle form has a high level of photocatalytic activity, and can be used for air and water purification and self-cleaning surfaces. Our findings, however, add to the current concern that this specific nanomaterial may have the potential to affect human health".

For this study, the researchers injected pregnant mice with Ti02 nanoparticles. The brains were obtained from male fetuses/pups on the 16th day of gestation and at several points after birth. Comparing these brains to those of control animals, the researchers were able to demonstrate changes in expression of hundreds of genes. According to Takeda, "Diseases associated with these genes include those we normally consider to develop in childhood, such as autistic disorder, epilepsy and learning disorders, and also others that arise mainly in adulthood or old age, such as Alzheimer's disease, schizophrenia and Parkinson's disease."

Nanotechnology deals with engineering at the molecular scale. Materials reduced to nanoparticles behave in ways dissimilar to those we're used to - altering their reactivity, surface area to volume and any number of other properties. While larger TiO2 particles are commonly used in paints and sunblocks, nanoparticles of TiO2 are specially created for new applications in coatings and self-cleaning surfaces and their effects on living tissue are only beginning to be understood. It should be noted that this gene expression data cannot be interpreted as a direct health effect. In addition, the nanoparticles were deliberately injected at a high dose, so the relevance to real-life exposure may be limited.


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Midori Shimizu, Hitoshi Tainaka, Taro Oba, Keisuke Mizuo, Masakazu Umezawa and Ken Takeda. Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Particle and Fibre Toxicology, (in press) [link]

Cite This Page:

BioMed Central. "Nanotech Particles Affect Brain Development In Mice." ScienceDaily. ScienceDaily, 30 July 2009. <www.sciencedaily.com/releases/2009/07/090728201737.htm>.
BioMed Central. (2009, July 30). Nanotech Particles Affect Brain Development In Mice. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2009/07/090728201737.htm
BioMed Central. "Nanotech Particles Affect Brain Development In Mice." ScienceDaily. www.sciencedaily.com/releases/2009/07/090728201737.htm (accessed October 1, 2014).

Share This



More Matter & Energy News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Argentina's Tax Evaders Detected, Hunted Down by Drones

Argentina's Tax Evaders Detected, Hunted Down by Drones

AFP (Sep. 30, 2014) Argentina doesn't only have Lionel Messi the footballer, it has now also acquired "Mesi" the drone system which monitors undeclared mansions, swimming pools and soy fields to curb tax evasion in the country. Duration: 01:18 Video provided by AFP
Powered by NewsLook.com
Do Video Games Trump Brain Training For Cognitive Boosts?

Do Video Games Trump Brain Training For Cognitive Boosts?

Newsy (Sep. 29, 2014) More and more studies are showing positive benefits to playing video games, but the jury is still out on brain training programs. Video provided by Newsy
Powered by NewsLook.com
CERN Celebrates 60 Years of Science

CERN Celebrates 60 Years of Science

Reuters - Business Video Online (Sep. 29, 2014) CERN, the European Organisation for Nuclear Research, celebrates 60 years of bringing nations together through science. As Joanna Partridge reports from inside the famous science centre it's also planning to turn the Large Hadron Collider particle accelerator back on after an upgrade. Video provided by Reuters
Powered by NewsLook.com
This 'Invisibility Cloak' Is Simpler Than Most

This 'Invisibility Cloak' Is Simpler Than Most

Newsy (Sep. 28, 2014) Researchers from the University of Rochester have created a type of invisibility cloak with simple focal lenses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins