Featured Research

from universities, journals, and other organizations

Long-term Health And Social Outcomes For Neuroblastoma Survivors

Date:
August 20, 2009
Source:
Journal of the National Cancer Institute
Summary:
Survivors of the childhood cancer neuroblastoma are eight times more likely to have chronic health conditions, less likely to be married, and more likely to have lower incomes than their siblings, according to a new study.

Survivors of the childhood cancer neuroblastoma are eight times more likely to have chronic health conditions, less likely to be married, and more likely to have lower incomes than their siblings, according to a study published online July 31 in the Journal of the National Cancer Institute.

Related Articles


This study was undertaken because minimal information exists on the long-term outcomes for neuroblastoma survivors.

Caroline Laverdiere, M.D., of the Sainte-Justine Hospital in Montreal, and colleagues looked at data for 954 5-year neuroblastoma survivors who were diagnosed from 1970-1986 and enrolled in the Childhood Cancer Survivor Study (CCSS). Late mortality, second malignant tumors, and chronic health conditions were analyzed. The researchers also compared participants with a cohort of 3,899 siblings of children with cancer for risk of chronic health conditions and sociodemographic outcomes.

Neuroblastoma survivors were less likely to be married or employed with high income than the controls from the sibling cohort, and after 20 years follow-up, were more than eight times more likely to have chronic health conditions, such as neurological, endocrine, sensory, and musculoskeletal complications.

"…[R]esults of the current study are quite relevant and underscore the need for close surveillance and life-long follow-up to ameliorate potential medical and psychosocial late effects," the authors write. "Future research should build on these data and investigate risk factors for long-term complications of neuroblastoma treatment and second malignant neoplasms…"

In an accompanying editorial, Elizabeth Fox, M.D., of the Pediatric Oncology Branch at the Center for Cancer Research, National Cancer Institute, in Bethesda, Md., Deborah Citron, M.D., of the Radiation Oncology Branch at NCI, and Frank M. Balis, M.D, of the Children's Hospital of Philadelphia, point out that survivors who were treated with multimodal therapy in this time frame had twice as much risk of late effects as survivors who had localized neuroblastomas that could be treated with surgery alone. Because surviving neuroblastoma patients from the 1970s were less likely than both current neuroblastoma patients and survivors of other childhood cancers from the 1970s to have been treated with intensive therapies, this population probably has fewer late-arising complications than might be expected for either of the latter two groups.

"The introduction of more selective and less toxic molecularly-targeted drugs holds the promise of substantially altering the acute and long-term toxic effects of cancer therapy," the editorialists write. "The potential requirement for extended treatment with these drugs may have a substantial impact on a child's development and will require careful study of late effects, similar to the ongoing efforts of the CCSS."


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Long-term Health And Social Outcomes For Neuroblastoma Survivors." ScienceDaily. ScienceDaily, 20 August 2009. <www.sciencedaily.com/releases/2009/07/090731191140.htm>.
Journal of the National Cancer Institute. (2009, August 20). Long-term Health And Social Outcomes For Neuroblastoma Survivors. ScienceDaily. Retrieved January 28, 2015 from www.sciencedaily.com/releases/2009/07/090731191140.htm
Journal of the National Cancer Institute. "Long-term Health And Social Outcomes For Neuroblastoma Survivors." ScienceDaily. www.sciencedaily.com/releases/2009/07/090731191140.htm (accessed January 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, January 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins