Featured Research

from universities, journals, and other organizations

New Function For Protein Missing In Duchenne Muscular Dystrophy Identified

Date:
August 5, 2009
Source:
University of Minnesota
Summary:
Researchers have identified a new function for the protein missing in people with the most common and ultimately lethal form of childhood muscular dystrophy.

Researchers at the University of Minnesota and National Institutes of Health have identified a new function for the protein missing in people with the most common and ultimately lethal form of childhood muscular dystrophy.

Related Articles


Patients with Duchenne muscular dystrophy lack the protein dystrophin, which causes their muscles to become weak and eventually die. Since its discovery in 1987, research has shown that dystrophin protects muscle cells by directly connecting to two of the three filament types that give cells their shape and durability. The new study demonstrates that dystrophin also directly links to the third structural filament type named microtubules. Microtubules form a highly ordered lattice in muscle, and the new study finds that microtubules become disorganized when dystrophin is missing.

"It's remarkable that scientists have been intensively studying dystrophin for more than 20 years, yet we continue to identify new features that better define its important contribution to healthy muscle." said James Ervasti, Ph.D., a professor in the Department of Biochemistry, Molecular Biology & Biophysics, who directed the investigation.

The new findings suggest that loss of microtubule organization might contribute to the devastating symptoms of Duchenne muscular dystrophy, information that will hopefully lead to the development of therapies to combat the disease. The study appears online Aug. 3, 2009 and will be published in the Aug. 10 issue of The Journal of Cell Biology.

 

The research was funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases.


Story Source:

The above story is based on materials provided by University of Minnesota. Note: Materials may be edited for content and length.


Cite This Page:

University of Minnesota. "New Function For Protein Missing In Duchenne Muscular Dystrophy Identified." ScienceDaily. ScienceDaily, 5 August 2009. <www.sciencedaily.com/releases/2009/08/090803173254.htm>.
University of Minnesota. (2009, August 5). New Function For Protein Missing In Duchenne Muscular Dystrophy Identified. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2009/08/090803173254.htm
University of Minnesota. "New Function For Protein Missing In Duchenne Muscular Dystrophy Identified." ScienceDaily. www.sciencedaily.com/releases/2009/08/090803173254.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) — Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) — Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) — AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com
Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) — Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins