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New DNA And RNA Aptamers Offer Unique Therapeutic Advantages

Date:
August 10, 2009
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
A novel class of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and are currently in clinical development as treatments for a broad range of common diseases, as described in a comprehensive review.

A novel class of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and are currently in clinical development as treatments for a broad range of common diseases, as described in a comprehensive review article published online ahead of print in Oligonucleotides.

Aptamers offer several advantages compared to protein or small molecule drugs, most notably their ease of production, low risk of inducing an immune reaction in humans, and amenability to chemical modifications that enhance their drug-like properties, including improved stability and residence time in the bloodstream. Aptamer therapeutics presently in clinical development target diseases and applications such as macular degeneration, coronary artery bypass graft surgery, and various types of cancer.

Kristina W. Thiel, PhD and Paloma H. Giangrande, PhD, from the University of Iowa, present a thorough review of aptamers and aptamer-based therapeutic strategies that have the highest likelihood of success. In the article entitled "Therapeutic Applications of DNA and RNA Aptamers," the authors describe the methods used to identify aptamers that specifically bind protein drug targets of interest, the types of modifications that have been made to aptamers to enhance their therapeutic potential, and the different types of aptamers that are currently in development. They also discuss the challenges that must still be overcome for aptamer technology to achieve its full potential.

"This is a comprehensive and timely review of aptamer development and therapeutic applications that our readers should enjoy," says John Rossi, PhD, Co-Editor-in-Chief of Oligonucleotides and Professor in the Department of Molecular Biology, Beckman Research Institute of the City of Hope (Duarte, CA).


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "New DNA And RNA Aptamers Offer Unique Therapeutic Advantages." ScienceDaily. ScienceDaily, 10 August 2009. <www.sciencedaily.com/releases/2009/08/090805133021.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2009, August 10). New DNA And RNA Aptamers Offer Unique Therapeutic Advantages. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2009/08/090805133021.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "New DNA And RNA Aptamers Offer Unique Therapeutic Advantages." ScienceDaily. www.sciencedaily.com/releases/2009/08/090805133021.htm (accessed October 20, 2014).

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