Featured Research

from universities, journals, and other organizations

Discovery Could Help Stem Infections Of Parasitic Roundworms

Date:
August 17, 2009
Source:
University of California - San Diego
Summary:
Biologists have discovered how a Chinese drug effective in killing parasitic roundworms works. Their discovery of the drug's biological mechanism provides important new information about how to combat parasitic roundworms, which infect more than a billion people in tropical regions and are one of the leading causes of debilitation in underdeveloped countries.

Scientists treat Burundi children infected with roundworms.
Credit: Photo by Jeanine Niyonzima-Aroian

Working with researchers in China, biologists at UC San Diego have discovered how a Chinese drug effective in killing parasitic roundworms works.

Their discovery of the drug's biological mechanism provides important new information about how to combat parasitic roundworms, which infect more than a billion people in tropical regions and are one of the leading causes of debilitation in underdeveloped countries. The researchers detail their findings in the current issue of the open-access journal PLoS Neglected Tropical Diseases.

Parasitic intestinal roundworms, such as hookworms—estimated to affect as many as 740 million people worldwide—and whipworms, which infect an estimated 795 million people, are considered by public-health officials to have a combined debilitating impact on human populations that is equal to or great than malaria or tuberculosis. But few drugs have been developed to effectively combat their infection.

"For practical reasons, only one drug, albendazole, is now widely used in administering single-dose treatments to large populations," said Raffi Aroian, a professor of biology at UCSD who headed the research effort. "But because of the enormous numbers of people that need to be treated and the necessity of repeated treatments due to high re-infection rates, the development of resistance to albendazole is a serious threat to large-scale de-worming efforts."

"We are studying this Chinese drug, tribendimidine, that clinically appears to be as good as albendazole," he added.

Developed by the Chinese Center for Disease Control and Prevention in Shanghai, tribendimidine has not yet been approved for human use. Recent clinical trials in China and Africa have found the drug to be effective in humans against some roundworm parasites, such as hookworms. But not much is known about the biological mechanisms by which the drug kills roundworms or the biochemical pathways through which roundworms can develop resistance to tribendimidine.

"This information is important for preventing, detecting and managing the resistance that some organisms can evolve to drugs," said Aroian. "It's also important in order to safely administer the drug to large populations and for knowing how to combine tribendimidine with other drugs."

Yan Hu, a postdoctoral fellow from China working in Aroian's laboratory, contacted Shu-Hua Xiao, a professor at the Chinese CDC in Shanghai, and began a two-year series of studies with the laboratory roundworm C. elegans that allowed her to determine tribendimidine's mechanism of action.

She did this by first developing genetic mutants resistant to tribendimidine and later analyzing another set of mutants to two other drugs used to treat roundworms—levamisole and pyrantel. Hu then determined that all of the mutants had the same genetic abnormalities, meaning that the biochemical pathways used to develop drug resistance in the animals were similar in all three. Mutants that develop resistance to albendazole, meanwhile, have a totally different set of genetic abnormalities.

Because levamisole and pyrantel are substantially less effective as albendazole in killing roundworms, these drugs are not the first choice for mass administration of drugs. But the results from Hu and her collaborators suggest that tribendimidine could be effectively used in areas instead of albendazole where parasites are likely to or have already developed a resistance to albendazole. Tribendimidine could also be combined with albendazole, the researchers said, to increase the effectiveness of killing parasitic roundworms, since both drugs have different biological killing mechanisms.

"Tribendimidine is not just a little bit different from albendazole," said Aroian. "It's in an entirely different class of drugs. The fact that tribendimidine is different from albendazole, but has the same level of effectiveness, and is in the same class as pyrantel and levamisole should increase people's comfort level in using this new drug."

The researchers were supported in their study by grants from the National Institutes of Health.


Story Source:

The above story is based on materials provided by University of California - San Diego. Note: Materials may be edited for content and length.


Cite This Page:

University of California - San Diego. "Discovery Could Help Stem Infections Of Parasitic Roundworms." ScienceDaily. ScienceDaily, 17 August 2009. <www.sciencedaily.com/releases/2009/08/090810221413.htm>.
University of California - San Diego. (2009, August 17). Discovery Could Help Stem Infections Of Parasitic Roundworms. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/08/090810221413.htm
University of California - San Diego. "Discovery Could Help Stem Infections Of Parasitic Roundworms." ScienceDaily. www.sciencedaily.com/releases/2009/08/090810221413.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins