Featured Research

from universities, journals, and other organizations

Novel Treatment Reduces Swollen Livers

Date:
August 18, 2009
Source:
Radboud University Nijmegen Medical Centre
Summary:
A novel treatment strategy for patients with many cysts in their liver led to a surprising result. A six month treatment with a synthetic gastrointestinal hormone lanreotide significantly decreased swollen cystic livers by approximately five percent, compared to a 'wait and see' policy.

A novel treatment strategy for patients with many cysts in their liver led to a surprising result, reported in the online version of Gastroenterology by researchers from Radboud University Nijmegen Medical Centre, The Netherlands. A six month treatment with a synthetic gastrointestinal hormone lanreotide significantly decreased swollen cystic livers by approximately five percent, compared to a ‘wait and see’ policy.

At least five percent of the population has one or two cysts in the liver. Cysts are fluid-filled cavities. There are also many patients who have numerous cysts, which then is termed a polycystic liver. These cysts cause the liver to grow to four to six times its normal size. Until recently, surgery was the only possible treatment for these patients, but this approach leads to many complications, and the outcome is not always successful. Ultimately, these patients need a liver transplantation, but in view of the limited availability of organs, only few are actually transplanted.

Hepatologist Prof. Drenth, from Radboud University Nijmegen Medical Centre, commented: "In Nijmegen, we had experience with the administration of synthetic gastrointestinal hormones in two polycystic liver patients. This treatment resulted in significantly smaller liver cysts. This stimulated us to proceed to a randomized clinical trial in 54 polycystic liver patients from Nijmegen (The Netherlands) and Leuven (Belgium). Computer tomography indicated that the size of the average liver was 4.6 liters, at least three times the normal size. Twenty-seven patients received a monthly injection of lanreotide, and results were compared with 27 patients who received a placebo injection. After six months with lanreotide, the liver size was reduced by 2.9 percent, while that of the placebo group increased by 1.6 percent. Lanreotide worked best for patients with the largest livers."

This novel approach allows physicians to avoid the prospect of surgery. In the Netherlands there is an estimated group of 17,000 patients with polycystic livers, three quarters will face surgery because of their disease.


Story Source:

The above story is based on materials provided by Radboud University Nijmegen Medical Centre. Note: Materials may be edited for content and length.


Journal Reference:

  1. van Keimpema L, Nevens F, Vanslembrouck R, van Oijen M.G., Hoffmann A.L., Dekker H.M., de Man R.A., Drenth J.P. Lanreotide Reduces the Volume of Polycystic Liver: A Randomized, Double-Blind, Placebo-Controlled Trial. Gastroenterology, 2009; DOI: 10.1053/j.gastro.2009.07.052

Cite This Page:

Radboud University Nijmegen Medical Centre. "Novel Treatment Reduces Swollen Livers." ScienceDaily. ScienceDaily, 18 August 2009. <www.sciencedaily.com/releases/2009/08/090814101835.htm>.
Radboud University Nijmegen Medical Centre. (2009, August 18). Novel Treatment Reduces Swollen Livers. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2009/08/090814101835.htm
Radboud University Nijmegen Medical Centre. "Novel Treatment Reduces Swollen Livers." ScienceDaily. www.sciencedaily.com/releases/2009/08/090814101835.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com
Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Carpenter's Injury Leads To Hundreds Of 3-D-Printed Hands

Newsy (Apr. 14, 2014) Richard van As lost all fingers on his right hand in a woodworking accident. Now, he's used the incident to create a prosthetic to help hundreds. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins