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New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer

Date:
August 26, 2009
Source:
World Journal of Gastroenterology
Summary:
Scientists systematically analyzed the expression of laminin-5 (LN5) chains and matrix metalloproteinase 7 in biliary tract cancer. They found that invasive front dominant expression of LN³2 and LN²3, and active MMP7 was associated with tumor progression. LN³2 and LN²3, in conjunction with MMP7, appear to play a key role in the progression of biliary tract cancer.
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Despite recent advances in diagnosis and treatment, the prognosis of patients with biliary tract cancer is still poor. Elucidating the biological characteristics of these carcinomas has become necessary to improve the prognosis of patients and to devise better treatment strategies. A recent study report that invasive front dominant expression of LNγ2 and LNβ3 and active MMP7 play a key role in the progression of biliary tract cancer.

The potential role of LN5 and MMP7 in human cancer is receiving increasing attention. However, expression of LN5 and MMP7 in biliary tract cancer has not been clearly addressed. A research article to be published on August 21,2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Hiroyuki Yamamoto of Sapporo Medical University systematically analyzed the expression of LN5 chains and MMP7 in biliary tract cancer.

Using RT-PCR, real-time RT-PCR, immunohistochemistry, casein zymography, and cell invasion assays, the research team analyzed the expression and role of LN5 and MMP7 in biliary tract cancer, in relation to clinicopathological characteristics. Invasive front dominant expression of LNγ2 and LNβ3 was associated with tumor progression. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Down-regulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in vitro.

In the view of Professor Hiroyuki Yamamoto, detection of LNγ2, LNβ3, and active MMP7 could be molecular markers for tumor aggressiveness in biliary tract cancer. Understanding how LNγ2, LNβ3, and active MMP7 are induced and how their expression is blocked may represent a future strategy for therapeutic intervention in the treatment of patients with biliary tract cancer.

Overexpression of LN5 chains, especially LNγ2, and MMP7 has been reported in various types of carcinomas, such as hepatocellular, colorectal, stomach, and esophagus. LN5 chains and MMP7 could be future therapeutic targets in clinical settings.


Story Source:

The above post is reprinted from materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Yasushi Adachi Y, Imai K, Shinomura Y. Overexpression of beta-3 and gamma 2 chains of laminin 5 and MMP7 in the progression of biliary tract cancer. World J Gastroenterol, 2009; 15(31):3865-3873

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World Journal of Gastroenterology. "New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer." ScienceDaily. ScienceDaily, 26 August 2009. <www.sciencedaily.com/releases/2009/08/090826105931.htm>.
World Journal of Gastroenterology. (2009, August 26). New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer. ScienceDaily. Retrieved July 6, 2015 from www.sciencedaily.com/releases/2009/08/090826105931.htm
World Journal of Gastroenterology. "New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/08/090826105931.htm (accessed July 6, 2015).

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