Featured Research

from universities, journals, and other organizations

New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer

Date:
August 26, 2009
Source:
World Journal of Gastroenterology
Summary:
Scientists systematically analyzed the expression of laminin-5 (LN5) chains and matrix metalloproteinase 7 in biliary tract cancer. They found that invasive front dominant expression of LN³2 and LN²3, and active MMP7 was associated with tumor progression. LN³2 and LN²3, in conjunction with MMP7, appear to play a key role in the progression of biliary tract cancer.

Despite recent advances in diagnosis and treatment, the prognosis of patients with biliary tract cancer is still poor. Elucidating the biological characteristics of these carcinomas has become necessary to improve the prognosis of patients and to devise better treatment strategies. A recent study report that invasive front dominant expression of LNγ2 and LNβ3 and active MMP7 play a key role in the progression of biliary tract cancer.

The potential role of LN5 and MMP7 in human cancer is receiving increasing attention. However, expression of LN5 and MMP7 in biliary tract cancer has not been clearly addressed. A research article to be published on August 21,2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Hiroyuki Yamamoto of Sapporo Medical University systematically analyzed the expression of LN5 chains and MMP7 in biliary tract cancer.

Using RT-PCR, real-time RT-PCR, immunohistochemistry, casein zymography, and cell invasion assays, the research team analyzed the expression and role of LN5 and MMP7 in biliary tract cancer, in relation to clinicopathological characteristics. Invasive front dominant expression of LNγ2 and LNβ3 was associated with tumor progression. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Down-regulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in vitro.

In the view of Professor Hiroyuki Yamamoto, detection of LNγ2, LNβ3, and active MMP7 could be molecular markers for tumor aggressiveness in biliary tract cancer. Understanding how LNγ2, LNβ3, and active MMP7 are induced and how their expression is blocked may represent a future strategy for therapeutic intervention in the treatment of patients with biliary tract cancer.

Overexpression of LN5 chains, especially LNγ2, and MMP7 has been reported in various types of carcinomas, such as hepatocellular, colorectal, stomach, and esophagus. LN5 chains and MMP7 could be future therapeutic targets in clinical settings.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Yasushi Adachi Y, Imai K, Shinomura Y. Overexpression of beta-3 and gamma 2 chains of laminin 5 and MMP7 in the progression of biliary tract cancer. World J Gastroenterol, 2009; 15(31):3865-3873

Cite This Page:

World Journal of Gastroenterology. "New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer." ScienceDaily. ScienceDaily, 26 August 2009. <www.sciencedaily.com/releases/2009/08/090826105931.htm>.
World Journal of Gastroenterology. (2009, August 26). New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2009/08/090826105931.htm
World Journal of Gastroenterology. "New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/08/090826105931.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins