Featured Research

from universities, journals, and other organizations

New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer

Date:
August 26, 2009
Source:
World Journal of Gastroenterology
Summary:
Scientists systematically analyzed the expression of laminin-5 (LN5) chains and matrix metalloproteinase 7 in biliary tract cancer. They found that invasive front dominant expression of LN³2 and LN²3, and active MMP7 was associated with tumor progression. LN³2 and LN²3, in conjunction with MMP7, appear to play a key role in the progression of biliary tract cancer.

Despite recent advances in diagnosis and treatment, the prognosis of patients with biliary tract cancer is still poor. Elucidating the biological characteristics of these carcinomas has become necessary to improve the prognosis of patients and to devise better treatment strategies. A recent study report that invasive front dominant expression of LNγ2 and LNβ3 and active MMP7 play a key role in the progression of biliary tract cancer.

The potential role of LN5 and MMP7 in human cancer is receiving increasing attention. However, expression of LN5 and MMP7 in biliary tract cancer has not been clearly addressed. A research article to be published on August 21,2009 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Hiroyuki Yamamoto of Sapporo Medical University systematically analyzed the expression of LN5 chains and MMP7 in biliary tract cancer.

Using RT-PCR, real-time RT-PCR, immunohistochemistry, casein zymography, and cell invasion assays, the research team analyzed the expression and role of LN5 and MMP7 in biliary tract cancer, in relation to clinicopathological characteristics. Invasive front dominant expression of LNγ2 and LNβ3 was associated with tumor progression. Active MMP7 detected by casein zymography was correlated with depth of invasion and advanced stage. Down-regulation of MMP7 expression by siRNA resulted in a significant decrease in biliary tract cancer cell invasion in vitro.

In the view of Professor Hiroyuki Yamamoto, detection of LNγ2, LNβ3, and active MMP7 could be molecular markers for tumor aggressiveness in biliary tract cancer. Understanding how LNγ2, LNβ3, and active MMP7 are induced and how their expression is blocked may represent a future strategy for therapeutic intervention in the treatment of patients with biliary tract cancer.

Overexpression of LN5 chains, especially LNγ2, and MMP7 has been reported in various types of carcinomas, such as hepatocellular, colorectal, stomach, and esophagus. LN5 chains and MMP7 could be future therapeutic targets in clinical settings.


Story Source:

The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Yasushi Adachi Y, Imai K, Shinomura Y. Overexpression of beta-3 and gamma 2 chains of laminin 5 and MMP7 in the progression of biliary tract cancer. World J Gastroenterol, 2009; 15(31):3865-3873

Cite This Page:

World Journal of Gastroenterology. "New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer." ScienceDaily. ScienceDaily, 26 August 2009. <www.sciencedaily.com/releases/2009/08/090826105931.htm>.
World Journal of Gastroenterology. (2009, August 26). New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2009/08/090826105931.htm
World Journal of Gastroenterology. "New Molecular Markers For Tumor Aggressiveness In Biliary Tract Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/08/090826105931.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) — A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins