Featured Research

from universities, journals, and other organizations

Novel Genetic Region Identified For Childhood Asthma In Mexicans

Date:
August 30, 2009
Source:
Public Library of Science
Summary:
Genetic variants in a region on chromosome 9q may influence asthma development in Mexican children, according to new research. Researchers conducted a genome-wide association study in which they looked at over 500,000 variants across the genome in 492 Mexican children with asthma and their parents to identify novel genes that may influence asthma development. The work points to the chromosome 9q21.31 region as a novel candidate region for childhood asthma.

Genetic variants in a region on chromosome 9q may influence asthma development in Mexican children, according to research published in the August 28 issue of the open-access journal PLoS Genetics.

Related Articles


Researchers from the National Institute of Environmental Health Sciences and the National Institute of Public Health (Mexico) and their collaborators at universities in the US and the UK conducted a genome-wide association (GWA) study, in which they looked at over 500,000 variants across the genome in 492 Mexican children with asthma and their parents to identify novel genes that may influence asthma development. The work points to the chromosome 9q21.31 region as a novel candidate region for childhood asthma.

Asthma is a leading chronic childhood disease that is influenced by both genetic and environmental factors. However, few genes have been consistently associated with the disease. GWA studies have successfully identified novel genes for many common diseases, but to date there have been only a handful of GWA studies focused on asthma and even fewer focused on asthma in Hispanic populations.

The researchers also examined ancestry in this Mexican population and found that the chromosome 9q21.31 region may underlie some of the differences in childhood asthma prevalence that have been observed across ethnic groups. It remains unclear why Mexicans have lower rates of asthma than some other groups.

The chromosome 9q21.31 variants associated with childhood asthma in this study are located near the TLE4 gene, but the researchers state that "further work is needed to decipher whether TLE4 or a nearby gene explains the signals from the chromosome 9q21.31 region." In addition, it is likely that multiple genetic and environmental risk factors underlie the development of childhood asthma, and the researchers conclude that studies with very large sample sizes will be needed to identify the important interacting risk factors.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hancock DB, Romieu I, Shi M, Sienra-Monge J-J, Wu H, et al. Genome-Wide Association Study Implicates Chromosome 9q21.31 as a Susceptibility Locus for Asthma in Mexican Children. PLoS Genetics, 2009; 5 (8): e1000623 DOI: 10.1371/journal.pgen.1000623

Cite This Page:

Public Library of Science. "Novel Genetic Region Identified For Childhood Asthma In Mexicans." ScienceDaily. ScienceDaily, 30 August 2009. <www.sciencedaily.com/releases/2009/08/090828103922.htm>.
Public Library of Science. (2009, August 30). Novel Genetic Region Identified For Childhood Asthma In Mexicans. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2009/08/090828103922.htm
Public Library of Science. "Novel Genetic Region Identified For Childhood Asthma In Mexicans." ScienceDaily. www.sciencedaily.com/releases/2009/08/090828103922.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins