Featured Research

from universities, journals, and other organizations

Protein–telomere Interactions Could Be Key In Treating Cancer

Date:
September 2, 2009
Source:
The Wistar Institute
Summary:
Researchers have shown that a large noncoding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division.

A team of researchers from The Wistar Institute have shown that a large non-coding RNA in mammals and yeast plays a central role in helping maintain telomeres, the tips of chromosomes that contain important genetic information and help regulate cell division. Since this RNA also facilitates the formation of DNA at telomeres—a process that can protect aging cells and destabilize tumor cells—manipulating its expression may be useful in treating cancer and other diseases.

Related Articles


The steady shortening of telomeres with each replication in somatic cells is linked to cellular aging, genetic instability, and tumor formation. This is because telomeres eventually "run out" after a certain number of cell divisions, resulting in the loss of vital genetic information from the cell's chromosome with future divisions. Scientists recently identified telomere-repeat-encoding RNA (TERRA) as an integral component of DNA within the telomeres of multiple species. The Wistar team demonstrated how TERRA mediates and partially stabilizes interactions between telomeric proteins that play essential roles in DNA replication.

"TERRA is a major component in helping protect the genome at a very sensitive place, the telomeres," said senior author Paul M. Lieberman, Ph.D., a professor in Wistar's Gene Expression and Regulation Program. "By managing TERRA levels we have the potential to regulate cellular aging and to impair the functioning of cancer cells."

TERRA associates with telomeric factors, but its precise function and mechanism of localization at telomeres had been largely unknown. In a study published on-line on August 27 in Molecular Cell, the Wistar scientists, led by Lieberman, describe how they discovered the telomere proteins that interact with TERRA and the processes by which they do so. In cell cultures, through RNA affinity purification, a process that isolates a single type of protein from a complex mixture, the team identified telomeric proteins (Shelterin components TRF1 and TRF2, and origin recognition complex subunits ORC1, ORC2, and ORC4) that bound to a TERRA oligonucleotide sequence but not to control oligonucleotides. Using RNA chromatin immunoprecipitation assays (ChIPs), in which specific pieces of RNA are isolated from bound proteins, the team discovered that TERRA is bound by telomeric proteins indicating that TERRA was a component of the Shelterin complex. The findings provide important clues that point to strategies for altering the expression of TERRA as a means to treat cancer and other diseases of aging, Lieberman says.

Study investigators also included Zhong Deng, Ph.D., staff scientist; Julie Norseen, predoctoral trainee; Andreas Wiedmer, research assistant; and Harold Riethman, Ph.D., associate professor.

This work was funded by grants from the National Institutes of Health, a Leukemia Lymphoma Society Special Fellow Award, and a University of Pennsylvania Training Grant in Tumor Virology.


Story Source:

The above story is based on materials provided by The Wistar Institute. Note: Materials may be edited for content and length.


Cite This Page:

The Wistar Institute. "Protein–telomere Interactions Could Be Key In Treating Cancer." ScienceDaily. ScienceDaily, 2 September 2009. <www.sciencedaily.com/releases/2009/08/090831213216.htm>.
The Wistar Institute. (2009, September 2). Protein–telomere Interactions Could Be Key In Treating Cancer. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2009/08/090831213216.htm
The Wistar Institute. "Protein–telomere Interactions Could Be Key In Treating Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/08/090831213216.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins