Featured Research

from universities, journals, and other organizations

New Asthma Predictors Needed To Determine Future Risk In Certain Patients

Date:
September 7, 2009
Source:
UT Southwestern Medical Center
Summary:
Screening tests used to predict asthma activity in patients may have little tracking success when applied to people with persistent disease who are adhering to their health care regimens, physicians report.

Screening tests used to predict asthma activity in patients may have little tracking success when applied to people with persistent disease who are adhering to their health care regimens, UT Southwestern Medical Center physicians report.

Related Articles


Previous reports have suggested that certain clinical findings and laboratory tests could help predict future asthma attacks. Those earlier conclusions, however, were based on observations of patients with poorly controlled asthma who had not received care based on current guidelines.

The new study appears in the August issue of the Journal of Allergy and Clinical Immunology.

“It was surprising to find that factors often used to predict future asthma risk in poorly treated populations were of no clinical benefit when applied to a well-treated, highly adherent population of inner-city adolescents and young adults with persistent asthma,” said Dr. Rebecca Gruchalla, chief of allergy and immunology at UT Southwestern and the new study’s lead author.

Early identification of adolescents and young adults at risk for asthma progression may lead to better treatment opportunities and improved disease outcomes in adulthood.

The study involved 546 adolescents and young adults between the ages of 12 and 20 with persistent asthma, a complex disease of the airways that is characterized by variable and recurring symptoms, airflow obstruction, bronchial hyperresponsiveness and underlying inflammation.

The patients, who were in 10 cities across the U.S., received care based on National Institutes of Health (NIH) guidelines for 46 weeks and adhered to the treatment regime. Despite the large number of disease characteristics examined, none was found to be particularly useful in predicting future disease activity.

In order to evaluate patient characteristics that best predicted future asthma symptoms and exacerbations, researchers looked at traditional measurements of disease activity, such as frequency of asthma symptoms and lung function, as well as various markers of inflammation and allergic hypersensitivity.

“These findings highlight the need for us to identify better clinical predictors of asthma morbidity in patients who are both well-treated and who are compliant with their treatment regimes,” said Dr. Gruchalla.

The work was supported by the National Institute of Allergy and Infectious Disease (part of the NIH) through the Inner-City Asthma Consortium (ICAC). ICAC is a $55.8 million, six-year project whose purpose is to investigate treatments and causes of asthma in urban children.

In addition to UT Southwestern, researchers from the Mount Sinai School of Medicine; Johns Hopkins University School of Medicine; Boston University School of Medicine; Rho Inc., Chapel Hill, N.C.; University of Arizona College of Medicine; University of Colorado Health Science Center; National Jewish Health, Denver; Washington University; Case Western Reserve University School of Medicine; Children’s Memorial Hospital, Chicago; Columbia University College of Physicians and Surgeons; University of Wisconsin School of Medicine and Public Health; and Children’s National Medical Center, Washington, D.C., participated in this study.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

UT Southwestern Medical Center. "New Asthma Predictors Needed To Determine Future Risk In Certain Patients." ScienceDaily. ScienceDaily, 7 September 2009. <www.sciencedaily.com/releases/2009/08/090831213221.htm>.
UT Southwestern Medical Center. (2009, September 7). New Asthma Predictors Needed To Determine Future Risk In Certain Patients. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2009/08/090831213221.htm
UT Southwestern Medical Center. "New Asthma Predictors Needed To Determine Future Risk In Certain Patients." ScienceDaily. www.sciencedaily.com/releases/2009/08/090831213221.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins