Featured Research

from universities, journals, and other organizations

Vaccine To Prevent Urinary Tract Infections Shows Early Promise

Date:
September 19, 2009
Source:
Public Library of Science
Summary:
Scientists have made an important step toward what could become the first vaccine in the US to prevent urinary tract infections, if the robust immunity achieved in mice can be reproduced in humans.

University of Michigan (U-M) scientists have made an important step toward what could become the first vaccine in the U.S. to prevent urinary tract infections, if the robust immunity achieved in mice can be reproduced in humans.

Related Articles


The findings are published September 18 in the open-access journal PLoS Pathogens.

Urinary tract infections (UTIs) affect 53 percent of women and 14 percent of men at least once in their lives. These infections lead to lost work time and 6.8 million medical provider's office visits, 1.3 million emergency room visits and 245,000 hospitalizations a year, with an annual cost of $2.4 billion in the United States.

To help combat this common health issue, the U-M scientists used a novel systematic approach, combining bioinformatics, genomics and proteomics, to look for key parts of the bacterium, Escherichia coli, that could be used in a vaccine to elicit an effective immune response. The team, led by Dr. Harry L.T. Mobley, Ph.D., screened 5,379 possible bacterial proteins and identified three strong candidates to use in a vaccine to prime the body to fight E. coli, the cause of most uncomplicated urinary tract infections. The vaccine prevented infection and produced key types of immunity when tested in mice.

Scientists have attempted to develop a vaccine for UTIs over the past two decades. This latest potential vaccine has features that may better its chances of success. It alerts the immune system to iron receptors on the surface of bacteria that perform a critical function allowing infection to spread. Administered in the nose, it induces an immune response in the body's mucosa, a first line of defense against invading pathogens. The response, also produced in mucosal tissue in the urinary tract, should help the body fight infection where it starts.

Mobley's team is currently testing more strains of E. coli obtained from women treated at U-M. Most of the strains produce the same iron-related proteins that cthe vaccine targets, an encouraging sign that the vaccine could work against many urinary tract infections. Mobley is seeking partners in clinical research to move the vaccine forward into a phase 1 trial in humans. If successful, this vaccine would take several more years to reach the market.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HLT. Mucosal Immunization with Iron Receptor Antigens Protects against Urinary Tract Infection. PLoS Pathog, 2009; 5(9): e1000586 DOI: 10.1371/journal.ppat.1000586

Cite This Page:

Public Library of Science. "Vaccine To Prevent Urinary Tract Infections Shows Early Promise." ScienceDaily. ScienceDaily, 19 September 2009. <www.sciencedaily.com/releases/2009/09/090918100023.htm>.
Public Library of Science. (2009, September 19). Vaccine To Prevent Urinary Tract Infections Shows Early Promise. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2009/09/090918100023.htm
Public Library of Science. "Vaccine To Prevent Urinary Tract Infections Shows Early Promise." ScienceDaily. www.sciencedaily.com/releases/2009/09/090918100023.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins