Featured Research

from universities, journals, and other organizations

Vaccine To Prevent Urinary Tract Infections Shows Early Promise

Date:
September 19, 2009
Source:
Public Library of Science
Summary:
Scientists have made an important step toward what could become the first vaccine in the US to prevent urinary tract infections, if the robust immunity achieved in mice can be reproduced in humans.

University of Michigan (U-M) scientists have made an important step toward what could become the first vaccine in the U.S. to prevent urinary tract infections, if the robust immunity achieved in mice can be reproduced in humans.

The findings are published September 18 in the open-access journal PLoS Pathogens.

Urinary tract infections (UTIs) affect 53 percent of women and 14 percent of men at least once in their lives. These infections lead to lost work time and 6.8 million medical provider's office visits, 1.3 million emergency room visits and 245,000 hospitalizations a year, with an annual cost of $2.4 billion in the United States.

To help combat this common health issue, the U-M scientists used a novel systematic approach, combining bioinformatics, genomics and proteomics, to look for key parts of the bacterium, Escherichia coli, that could be used in a vaccine to elicit an effective immune response. The team, led by Dr. Harry L.T. Mobley, Ph.D., screened 5,379 possible bacterial proteins and identified three strong candidates to use in a vaccine to prime the body to fight E. coli, the cause of most uncomplicated urinary tract infections. The vaccine prevented infection and produced key types of immunity when tested in mice.

Scientists have attempted to develop a vaccine for UTIs over the past two decades. This latest potential vaccine has features that may better its chances of success. It alerts the immune system to iron receptors on the surface of bacteria that perform a critical function allowing infection to spread. Administered in the nose, it induces an immune response in the body's mucosa, a first line of defense against invading pathogens. The response, also produced in mucosal tissue in the urinary tract, should help the body fight infection where it starts.

Mobley's team is currently testing more strains of E. coli obtained from women treated at U-M. Most of the strains produce the same iron-related proteins that cthe vaccine targets, an encouraging sign that the vaccine could work against many urinary tract infections. Mobley is seeking partners in clinical research to move the vaccine forward into a phase 1 trial in humans. If successful, this vaccine would take several more years to reach the market.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HLT. Mucosal Immunization with Iron Receptor Antigens Protects against Urinary Tract Infection. PLoS Pathog, 2009; 5(9): e1000586 DOI: 10.1371/journal.ppat.1000586

Cite This Page:

Public Library of Science. "Vaccine To Prevent Urinary Tract Infections Shows Early Promise." ScienceDaily. ScienceDaily, 19 September 2009. <www.sciencedaily.com/releases/2009/09/090918100023.htm>.
Public Library of Science. (2009, September 19). Vaccine To Prevent Urinary Tract Infections Shows Early Promise. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2009/09/090918100023.htm
Public Library of Science. "Vaccine To Prevent Urinary Tract Infections Shows Early Promise." ScienceDaily. www.sciencedaily.com/releases/2009/09/090918100023.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins