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Matripase Critical For Epithelial Function

Date:
September 28, 2009
Source:
American Journal of Pathology
Summary:
Scientists report that the serum protease matripase is required for global homeostasis of diverse epithelial tissues.

A group led by Dr. Thomas Bugge of the National Institutes of Health in Bethesda, MD reports that the serum protease matripase is required for global homeostasis of diverse epithelial tissues.

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Epithelial cells line the surfaces of cavities and structures throughout the body. These cells have multiple general and organ-specific functions, including maintaining ion gradients, transporting molecules, secreting hormones and growth factors, and excluding pathogens.

The serum protease matripase plays a critical role in the function of epithelial cells in the skin; however, matripase is broadly expressed in different types of epithelial tissues. To explore the role of matripase on other epithelial tissues, List et al generated matripase-deficient mice. The loss of matripase was associated with severe organ dysfunction in multiple tissues; these epithelial tissues lost key epithelial functions.

The data by Dr. Bugge and colleagues "all strongly argue for a primary role of matriptase in tissue homeostasis, rather than a role in the restoration of homeostasis after chance injury to epithelial tissues. … This study has revealed an essential role of matriptase in the maintenance of global epithelial homeostasis in the mouse and has provided an important animal model for the further exploration of matriptase function in multiple physiological and pathological processes."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. List et al. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway. American Journal Of Pathology, 2009; 175 (4): 1453 DOI: 10.2353/ajpath.2009.090240

Cite This Page:

American Journal of Pathology. "Matripase Critical For Epithelial Function." ScienceDaily. ScienceDaily, 28 September 2009. <www.sciencedaily.com/releases/2009/09/090928095216.htm>.
American Journal of Pathology. (2009, September 28). Matripase Critical For Epithelial Function. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2009/09/090928095216.htm
American Journal of Pathology. "Matripase Critical For Epithelial Function." ScienceDaily. www.sciencedaily.com/releases/2009/09/090928095216.htm (accessed January 31, 2015).

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