Featured Research

from universities, journals, and other organizations

Gene Could Lead To New Therapies For Bone Marrow Disease

Date:
September 29, 2009
Source:
Van Andel Research Institute
Summary:
Researchers are one step closer to finding new ways to treat myelodysplastic syndrome (MDS), a bone marrow disease that strikes up to 15,000 people each year in the United States, and that sometimes results in acute myeloid leukemia. Researchers found that the gene RhoB is important to the disease's progression and could prove to be a therapeutic target for late-stage MDS.

Van Andel Research Institute (VARI) researchers are one step closer to finding new ways to treat Myelodysplastic Syndrome (MDS), a bone marrow disease that strikes up to 15,000 people each year in the United States, and that sometimes results in acute myeloid leukemia. Researchers found that the gene RhoB is important to the disease’s progression and could prove to be a therapeutic target for late-stage MDS.

Related Articles


“Using our genetic models, we’ve been able to provide a better understanding of underlying molecular defects that drive the malignant progression of MDS,” said VARI Distinguished Scientific Investigator Art Alberts, Ph.D., whose laboratory recently published its findings in the journal PLoS ONE. “The genes that we’ve focused on in this study might have a role not only in leukemia, but in solid tumors as well.”

Alberts’ lab previously reported that the Drf1 gene is crucial to the development of MDS. In its recent study, the lab found that the RhoB gene is important as well; lack of the proteins that are the product of the gene accelerates the disease’s progression. The researchers believe examining RhoB levels in samples from patients with advanced MDS could help direct them to better treatment options.

“Our goal is to identify novel therapeutic targets and develop new drugs that affect their activity, but also to find ways to improve upon existing therapeutic strategies that are often associated with deleterious side effects,” said Alberts.

“This recent work of Dr. Alberts builds on earlier knowledge from his laboratory yielding important insights into how the body controls the growth of red blood cells,” said VARI President and Research Director Dr. Jeffrey Trent. “This breakthrough in our knowledge has the potential to provide us with both new avenues of research, as well as new insights to develop improved treatments for MDS, and other disorders.”

In MDS, cells in the bone marrow don’t create enough blood cells, and many of the blood cells they do create are abnormal. The body destroys the abnormal blood cells, resulting in low blood counts that can lead to fatigue, impaired immunity, easy bruising and bleeding, and other symptoms. According to the American Cancer Society, 80 to 90 % of all patients with MDS are older than 60 years. In about one third of patients, MDS turns into acute myeloid leukemia, a fast-growing bone marrow cancer.

Lead author of the study Aaron DeWard said that the genetic models that the lab is using are key to translating their discoveries into therapies. “The models allow us to identify and test novel therapeutics and ask more clinically relevant questions,” said DeWard.

The lab collaborated with George C. Prendergast, Ph.D., from the Lankenau Institute for Medical Research on the study. The study was funded in part by grant number RSG-05-033-01-CSM from the American Cancer Society.


Story Source:

The above story is based on materials provided by Van Andel Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

Van Andel Research Institute. "Gene Could Lead To New Therapies For Bone Marrow Disease." ScienceDaily. ScienceDaily, 29 September 2009. <www.sciencedaily.com/releases/2009/09/090928172357.htm>.
Van Andel Research Institute. (2009, September 29). Gene Could Lead To New Therapies For Bone Marrow Disease. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2009/09/090928172357.htm
Van Andel Research Institute. "Gene Could Lead To New Therapies For Bone Marrow Disease." ScienceDaily. www.sciencedaily.com/releases/2009/09/090928172357.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins