Featured Research

from universities, journals, and other organizations

New Vaccine Delivery May Be More Effective Against Measles

Date:
September 29, 2009
Source:
American Association of Pharmaceutical Scientists
Summary:
Researchers are developing new methods for delivering measles vaccines that could potentially reduce costs and improve safety. While vaccines exist to protect children against measles, the vaccines are often difficult to store, costly to transport and may be prone to contamination when shipped to developing countries.

Worldwide, there are estimated to be 10 million cases of measles and 197,000 deaths from the disease each year. While vaccines exist to protect children against measles, the vaccines are often difficult to store, costly to transport and may be prone to contamination when shipped to developing countries. Research to be presented at the 2009 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition will reveal new methods for delivering measles vaccines that could potentially reduce costs and improve safety.

Related Articles


"Vaccination has become controversial in some international communities which believe vaccines might be hazardous," said Robert Sievers, Ph.D., from the University of Colorado and one of the study's principal investigators. "However, in many parts of the world, the disease itself is a serious hazard, killing hundreds of thousands of children each year."

While a liquid vaccine using a hypodermic needle is presently the only way to prevent the disease, Dr. Sievers' study shows promise for a new method that allows the patient to inhale a finely-powdered. In order to produce the inhalant, the weakened measles virus must be mixed with high-pressure carbon dioxide to produce microscopic bubbles and droplets, which are then gently dried to produce an inhalable powder. The powder is then puffed into a small inhaler-like device and administered. The aerosol vaccine was shown effective in test animals, and human trials are expected to begin next year in India, where more than half of the world's measles cases occur.

Researchers from Aridis Pharmaceuticals also have been working to develop a room temperature stable measles formulation that can be easily inhaled using cost-effective dry-powder inhalers in collaboration with the non-profit foundation PATH. According to Satoshi Ohtake, Ph.D., from Aridis and the study's principal investigator, "There is a need for technologies that could stabilize the measles vaccine, as this would facilitate mass vaccination in developing world countries where transport, storage, administration costs and other complexities have limited vaccine coverage by 70 percent."

Dr. Ohtake's study used a combination of mild spray drying process conditions and unique stabilizers to produce stable dry powders with excellent preservation of vaccine activity. The potency of the dried vaccine was then tested while being stored at different temperatures over several week-long periods. The results found that the dry-powdered aerosol was stable for at least eight weeks at 37C, surpassing the World Health Organization requirement for heat stability of one week at similar storage conditions.

"This study offers hope for developing countries that desperately need more stable and efficient vaccination methods," says Dr. Ohtake. "This new method could potentially offer safer, more affordable and effective treatments to patients that need them the most."


Story Source:

The above story is based on materials provided by American Association of Pharmaceutical Scientists. Note: Materials may be edited for content and length.


Cite This Page:

American Association of Pharmaceutical Scientists. "New Vaccine Delivery May Be More Effective Against Measles." ScienceDaily. ScienceDaily, 29 September 2009. <www.sciencedaily.com/releases/2009/09/090928172526.htm>.
American Association of Pharmaceutical Scientists. (2009, September 29). New Vaccine Delivery May Be More Effective Against Measles. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2009/09/090928172526.htm
American Association of Pharmaceutical Scientists. "New Vaccine Delivery May Be More Effective Against Measles." ScienceDaily. www.sciencedaily.com/releases/2009/09/090928172526.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com
AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

AbbVie Inks $21B Deal To Buy Cancer Drugmaker Pharmacyclics

Newsy (Mar. 5, 2015) AbbVie announced Wednesday it will buy cancer drugmaker Pharmacyclics in a $21 billion deal. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins