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New Approach To Targeting The Hidden Reservoir Of HIV

Date:
October 4, 2009
Source:
Journal of Clinical Investigation
Summary:
The drugs used to treat individuals infected with HIV-1 keep the virus under control but do not eliminate it from the body, some remains hidden in immune cells known as resting CD4+ T cells. However, researchers have now developed an in vitro system that faithfully mimics the situation in people and used it to identify a compound that can get at this hidden HIV-1 and eliminate it from the cells.

The drugs used to treat individuals infected with HIV-1 keep the virus under control and dramatically improve prognosis, but they do not eliminate the virus from the body completely, some remains hidden in immune cells known as resting CD4+ T cells. There are currently no clinically acceptable strategies for eliminating this reservoir of HIV-1.

However, Robert Siliciano and colleagues, at Johns Hopkins University School of Medicine, Baltimore, have developed an in vitro system that mimics the situation in people and used it to identify a compound that can get at this hidden HIV-1 and eliminate it from the CD4+ T cells. The researchers report their results in the Journal of Clinical Investigation.

Importantly, this compound does not cause global T cell activation, the side effect that has made other approaches to eliminating the HIV-1 reservoir clinically unacceptable. However, it has other potential toxicity issues that are likely to preclude its use in the clinic.

The authors therefore hope to use their in vitro system to screen more compounds so that a clinically acceptable drug that eliminates HIV-1 can be developed.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hung-Chih Yang, Sifei Xing, Liang Shan, Karen O%u2019Connell, Jason Dinoso, Anding Shen, Yan Zhou, Cynthia K. Shrum, Yefei Han, Jun O. Liu, Hao Zhang, Joseph B. Margolick, Robert F. Siliciano. Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39199

Cite This Page:

Journal of Clinical Investigation. "New Approach To Targeting The Hidden Reservoir Of HIV." ScienceDaily. ScienceDaily, 4 October 2009. <www.sciencedaily.com/releases/2009/10/091001181041.htm>.
Journal of Clinical Investigation. (2009, October 4). New Approach To Targeting The Hidden Reservoir Of HIV. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/10/091001181041.htm
Journal of Clinical Investigation. "New Approach To Targeting The Hidden Reservoir Of HIV." ScienceDaily. www.sciencedaily.com/releases/2009/10/091001181041.htm (accessed July 22, 2014).

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