Featured Research

from universities, journals, and other organizations

New Approach To Targeting The Hidden Reservoir Of HIV

Date:
October 4, 2009
Source:
Journal of Clinical Investigation
Summary:
The drugs used to treat individuals infected with HIV-1 keep the virus under control but do not eliminate it from the body, some remains hidden in immune cells known as resting CD4+ T cells. However, researchers have now developed an in vitro system that faithfully mimics the situation in people and used it to identify a compound that can get at this hidden HIV-1 and eliminate it from the cells.

The drugs used to treat individuals infected with HIV-1 keep the virus under control and dramatically improve prognosis, but they do not eliminate the virus from the body completely, some remains hidden in immune cells known as resting CD4+ T cells. There are currently no clinically acceptable strategies for eliminating this reservoir of HIV-1.

However, Robert Siliciano and colleagues, at Johns Hopkins University School of Medicine, Baltimore, have developed an in vitro system that mimics the situation in people and used it to identify a compound that can get at this hidden HIV-1 and eliminate it from the CD4+ T cells. The researchers report their results in the Journal of Clinical Investigation.

Importantly, this compound does not cause global T cell activation, the side effect that has made other approaches to eliminating the HIV-1 reservoir clinically unacceptable. However, it has other potential toxicity issues that are likely to preclude its use in the clinic.

The authors therefore hope to use their in vitro system to screen more compounds so that a clinically acceptable drug that eliminates HIV-1 can be developed.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hung-Chih Yang, Sifei Xing, Liang Shan, Karen O%u2019Connell, Jason Dinoso, Anding Shen, Yan Zhou, Cynthia K. Shrum, Yefei Han, Jun O. Liu, Hao Zhang, Joseph B. Margolick, Robert F. Siliciano. Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39199

Cite This Page:

Journal of Clinical Investigation. "New Approach To Targeting The Hidden Reservoir Of HIV." ScienceDaily. ScienceDaily, 4 October 2009. <www.sciencedaily.com/releases/2009/10/091001181041.htm>.
Journal of Clinical Investigation. (2009, October 4). New Approach To Targeting The Hidden Reservoir Of HIV. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/10/091001181041.htm
Journal of Clinical Investigation. "New Approach To Targeting The Hidden Reservoir Of HIV." ScienceDaily. www.sciencedaily.com/releases/2009/10/091001181041.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins