Featured Research

from universities, journals, and other organizations

Mutated FGFR4 Protein Helps A Childhood Cancer Spread

Date:
October 5, 2009
Source:
Journal of Clinical Investigation
Summary:
In patients with the childhood cancer rhabdomyosarcoma whose disease has spread from the initial tumor site, long-term survival is rare. Hopes for a therapy for such patients are not high, as little is known about the factors that control tumor progression and spread. However, new research now indicates that the protein FGFR4 has a role in rhabdomyosarcoma progression and suggests that it could be a potential drug target for treating the disease.

Rhabdomyosarcoma (RMS) is a childhood cancer thought to originate from skeletal muscle. In patients whose disease has spread (metastasized) from the initial tumor site the chance of long-term survival is poor. Hopes for a therapy for such patients are not high, as little is known about the factors that control tumor progression and metastasis.

Related Articles


However, Javed Khan and colleagues, at the National Cancer Institute, Bethesda, have now determined that the protein FGFR4 has a role in RMS progression and have data suggesting that it might be a good drug target for the treatment of individuals with RMS.

Results of the research appear in the Journal of Clinical Investigation.

In the study, higher levels of expression of the FGFR4 gene were found to be associated with advanced-stage cancer and poor survival. Conversely, reducing FGFR4 expression in a human RMS cell line decreased its ability to grow and metastasize when transplanted into mice.

Further analysis identified mutations in the FGFR4 gene in 7.5% of human RMS tumor samples analyzed. When two of the FGFR4 mutants generated by these genetic mutations were analyzed further, they were found to be constitutively activated forms of FGFR4 that increased the proliferative, invasive, and metastatic capacities of a murine RMS cell line.

Importantly, treatment with a pharmacologic inhibitor of FGFRs made the murine RMS cells expressing the FGFR4 mutants very susceptible to death, leading the authors to suggest that targeting FGFR4 might be of therapeutic benefit in RMS.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. James G. Taylor VI, Adam T. Cheuk, Patricia S. Tsang, Joon-Yong Chung, Young K. Song, Krupa Desai, Yanlin Yu, Qing-Rong Chen, Kushal Shah, Victoria Youngblood, Jun Fang, Su Young Kim, Choh Yeung, Lee J. Helman, Arnulfo Mendoza, Vu Ngo, Louis M. Staudt, Jun S. Wei, Chand Khanna, Daniel Catchpoole, Stephen J. Qualman, Stephen M. Hewitt, Glenn Merlino, Stephen J. Chanock, Javed Khan. Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J. Clin. Invest., 2009; DOI: 10.1172/JCI39703

Cite This Page:

Journal of Clinical Investigation. "Mutated FGFR4 Protein Helps A Childhood Cancer Spread." ScienceDaily. ScienceDaily, 5 October 2009. <www.sciencedaily.com/releases/2009/10/091005181225.htm>.
Journal of Clinical Investigation. (2009, October 5). Mutated FGFR4 Protein Helps A Childhood Cancer Spread. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/10/091005181225.htm
Journal of Clinical Investigation. "Mutated FGFR4 Protein Helps A Childhood Cancer Spread." ScienceDaily. www.sciencedaily.com/releases/2009/10/091005181225.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins