Featured Research

from universities, journals, and other organizations

Iron Regulates The TLR4 Inflammatory Signaling Pathway

Date:
October 5, 2009
Source:
Journal of Clinical Investigation
Summary:
Iron is a micronutrient essential to the survival of both humans and disease-causing microbes. Changes in iron levels therefore affect the severity of infectious diseases. New research has now identified an immune pathway affected by changes in iron levels that alter the susceptibility of mice to infection with the bacterium that causes salmonella, leading the researchers to suggest that local manipulation of iron levels might provide a new approach to controlling inflammation.

Iron is a micronutrient essential to the survival of both humans and disease-causing microbes. Changes in iron levels therefore affect the severity of infectious diseases. For example, individuals with mutations in their HFE gene have exceedingly high levels of iron in their liver and are more susceptible to infection with a number of microbes.

Related Articles


Exactly how changes in iron levels affect susceptibility to infectious disease has not been clearly determined, although it has been observed that mice lacking Hfe mount an impaired inflammatory response following oral infection with the bacterium that causes salmonella.

Bobby Cherayil and colleagues, at Massachusetts General Hospital, Charlestown, have now defined a molecular mechanism underlying the impaired inflammatory response to oral infection with the bacterium that causes salmonella in mice lacking Hfe. Results of the research appear in the Journal of Clinical Investigation.

Specifically, these mice have low levels of free iron in immune cells known as macrophages and this impairs signaling along a pathway required for sensing the presence of bacteria such as the one that causes salmonella and triggering an inflammatory response (the TLR4/TRAM/TRIF pathway).

As drugs that mimic the altered iron distribution associated with Hfe deficiency reduced intestinal damage associated with infection with the salmonella-causing bacterium and reduced intestinal damage in a noninfectious inflammatory situation, the authors suggest that local manipulation of iron levels might provide a new approach to controlling inflammation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lijian Wang, Lynne Harrington, Estela Trebicka, Hai Ning Shi, Jonathan C. Kagan, Charles C. Hong, Herbert Y. Lin, Jodie L. Babitt, Bobby J. Cherayil. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J. Clin. Invest., 2009; DOI: 10.1172/JCI39939

Cite This Page:

Journal of Clinical Investigation. "Iron Regulates The TLR4 Inflammatory Signaling Pathway." ScienceDaily. ScienceDaily, 5 October 2009. <www.sciencedaily.com/releases/2009/10/091005181227.htm>.
Journal of Clinical Investigation. (2009, October 5). Iron Regulates The TLR4 Inflammatory Signaling Pathway. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2009/10/091005181227.htm
Journal of Clinical Investigation. "Iron Regulates The TLR4 Inflammatory Signaling Pathway." ScienceDaily. www.sciencedaily.com/releases/2009/10/091005181227.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins