Featured Research

from universities, journals, and other organizations

Discovery Of Genetic Defect May Lead To Better Treatments For Common Gut Diseases

Date:
October 10, 2009
Source:
Indiana University School of Medicine
Summary:
New research related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens.

New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract.

Researchers from the United States and Canada have identified a genetic defect not previously known to be a cause of chronic granulomatous disease (CGD), an inherited disorder with recurrent bacterial and fungal infections. Some patients also develop gastrointestinal inflammation, as occurred in the patient in whom the new gene defect was discovered. CGD, which occurs in 1 in 200,000, is usually diagnosed in childhood.

In addition to providing insight into CGD, a condition in which an enzyme defect prevents white blood cells in the body from killing invading bacteria, the new findings highlight how abnormal white blood cell function can predispose individuals to IBD, and may help provide insight into why IBD develops. Crohn's disease and ulcerative colitis are the most common forms of IBD.

The research was led by Mary Dinauer, M.D., Ph.D., of the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine and Riley Hospital for Children, Nicola Wright, M.D., and colleagues at the Alberta Children's Hospital and the University of Calgary, and William Nauseef, M.D., of the University of Iowa. The new findings are reported in the October 8 print edition of the journal Blood.

"We now know that a genetic defect that selectively affects the production of oxidants inside of white blood cells can cause gastrointestinal symptoms of CGD. Exploring the gene defect's role in inflammatory bowel disease and immune processes will be a key priority in the future," said Dr. Dinauer, Nora Letzter Professor of Pediatrics at the IU School of Medicine. An internationally respected researcher, Dr. Dinauer is also a practicing hematologist/oncologist at Riley Hospital and a member of the Indiana University Melvin and Bren Simon Cancer Center.

The study was funded by the National Institutes of Health.


Story Source:

The above story is based on materials provided by Indiana University School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Juan D. Matute, Andres A. Arias, Nicola A. M. Wright, Iwona Wrobel, Christopher C. M. Waterhouse, Xing Jun Li, Christophe C. Marchal, Natalie D. Stull, David B. Lewis, MacGregor Steele, James D. Kellner, Weiming Yu, Samy O. Meroueh, William M. Nauseef, and Mary C. Dinauer. A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity. Blood, 2009; 114: 3309-3315

Cite This Page:

Indiana University School of Medicine. "Discovery Of Genetic Defect May Lead To Better Treatments For Common Gut Diseases." ScienceDaily. ScienceDaily, 10 October 2009. <www.sciencedaily.com/releases/2009/10/091008161906.htm>.
Indiana University School of Medicine. (2009, October 10). Discovery Of Genetic Defect May Lead To Better Treatments For Common Gut Diseases. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/10/091008161906.htm
Indiana University School of Medicine. "Discovery Of Genetic Defect May Lead To Better Treatments For Common Gut Diseases." ScienceDaily. www.sciencedaily.com/releases/2009/10/091008161906.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins