Featured Research

from universities, journals, and other organizations

Mechanism That Helps Bacteria Avoid Destruction In Cells Identified

Date:
October 12, 2009
Source:
Thomas Jefferson University
Summary:
Infectious diseases currently cause about one-third of all human deaths worldwide, more than all forms of cancer combined. Advances in cell biology and microbial genetics have greatly enhanced understanding of the cause and mechanisms of infectious diseases. Researchers have now found a way in which intracellular pathogens exploit the biological attributes of their hosts in order to escape destruction.

Infectious diseases currently cause about one-third of all human deaths worldwide, more than all forms of cancer combined. Advances in cell biology and microbial genetics have greatly enhanced understanding of the cause and mechanisms of infectious diseases. Researchers from Thomas Jefferson University, the Pasteur Institute in Paris, and Yale University reported in PLoS ONE, a way in which intracellular pathogens exploit the biological attributes of their hosts in order to escape destruction.

Related Articles


Intracellular pathogens include Chlamydia, which causes infertility in women, and Legionella, which causes Legionnaire's disease. These pathogens are able to escape destruction and remain in the cells. Until now, it was unclear how they were able avoid the destruction process. The team of researchers, led by Fabienne Paumet, Ph.D., assistant professor of Microbiology and Immunology at Jefferson Medical College of Thomas Jefferson University, found that it appears to be due to SNARE-like proteins expressed by the pathogen.

SNARE proteins are necessary for eukaryotic cells to fuse to their intracellular compartments. These proteins, which are present on the surface of almost all intracellular compartments, interact to form a stable complex, triggering fusion of the membranes. Intracellular pathogens, like Chlamydia and Legionella, must contend with vesicular trafficking and membrane fusion in the host cell. But they manage to bypass the lysosome, where other pathogens would normally be destroyed.

The researchers tested the hypothesis that SNARE-like proteins expressed by the bacteria themselves were capable to interact with the eukaryotic SNAREs and alter membrane fusion to their advantage. The Chlamydia bacteria expressed a SNARE-like protein called IncA and the Legionella expressed a SNARE-like protein called IcmG/DotF, both of which inhibit SNARE-protein-mediated fusion.

"Based on our results, it seems that intracellular bacteria are able to express 'inhibitory SNAREs' to block fusion between the lysosome and the compartment containing the bacteria," Dr. Paumet said. "The SNARE proteins function like a zipper, and without each half, they can't fuse."

SNARE-like bacterial proteins would appear to be a viable therapeutic target, since disruption of their protective function should render intracellular bacteria more susceptible to clearance from the phagosome.

"Thorough understanding of the bacterial SNARE-like protein system will give us the necessary tools to design such therapeutics," Dr. Paumet said.


Story Source:

The above story is based on materials provided by Thomas Jefferson University. Note: Materials may be edited for content and length.


Cite This Page:

Thomas Jefferson University. "Mechanism That Helps Bacteria Avoid Destruction In Cells Identified." ScienceDaily. ScienceDaily, 12 October 2009. <www.sciencedaily.com/releases/2009/10/091009204015.htm>.
Thomas Jefferson University. (2009, October 12). Mechanism That Helps Bacteria Avoid Destruction In Cells Identified. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/10/091009204015.htm
Thomas Jefferson University. "Mechanism That Helps Bacteria Avoid Destruction In Cells Identified." ScienceDaily. www.sciencedaily.com/releases/2009/10/091009204015.htm (accessed October 24, 2014).

Share This



More Plants & Animals News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins