Featured Research

from universities, journals, and other organizations

A Balancing Act In Parkinson's Disease: Phosphorylation Of Alpha-synuclein

Date:
October 12, 2009
Source:
Journal of Clinical Investigation
Summary:
Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. Previous studies have indicated that phosphorylation of alpha-synuclein at amino acid 129 is a key event in alpha-synuclein-mediated nerve cell toxicity. However, researchers have now identified a counterbalancing role in nerve cell protection for phosphorylation of alpha-synuclein amino acid 125.

Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. Previous studies have indicated that phosphorylation of alpha-synuclein at amino acid 129 (Ser129) is a key event in alpha-synuclein–mediated nerve cell toxicity.

Related Articles


However, Mel Feany and colleagues, at Brigham and Women's Hospital, Boston, have now identified a counterbalancing role in nerve cell protection for phosphorylation of alpha-synuclein amino acid 125 (Tyr125).

The research appears in the Journal of Clinical Investigation.

In the study, phosphorylation of human alpha-synuclein Tyr125 was detected in Drosophila transgenic for human alpha-synuclein and shown to protect from alpha-synuclein–mediated nerve cell toxicity in a Drosophila model of Parkinson disease.

That the two phosphorylated amino acids have opposing roles was indicated by the observation that Tyr125 phosphorylation decreased levels of toxic soluble alpha-synuclein oligomers in the Drosophila brain, whereas Ser129 phosphorylation increased them.

More importantly, Tyr125 phosphorylation was found to decrease as both humans and Drosophila aged and was reduced in cortical tissue from patients with synucleinopathy dementia with Lewy bodies, a disease related to Parkinson disease.

The authors therefore suggest that changes in the balance between Ser129 and Tyr125 phosphorylation — which promote nerve cell toxicity and protection, respectively — might cause alpha-synuclein–mediated nerve cell toxicity in Parkinson disease and related disorders.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chen et al. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. Journal of Clinical Investigation, 2009; DOI: 10.1172/JCI39088

Cite This Page:

Journal of Clinical Investigation. "A Balancing Act In Parkinson's Disease: Phosphorylation Of Alpha-synuclein." ScienceDaily. ScienceDaily, 12 October 2009. <www.sciencedaily.com/releases/2009/10/091012225801.htm>.
Journal of Clinical Investigation. (2009, October 12). A Balancing Act In Parkinson's Disease: Phosphorylation Of Alpha-synuclein. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2009/10/091012225801.htm
Journal of Clinical Investigation. "A Balancing Act In Parkinson's Disease: Phosphorylation Of Alpha-synuclein." ScienceDaily. www.sciencedaily.com/releases/2009/10/091012225801.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins