Featured Research

from universities, journals, and other organizations

Could Drugs For Mood Disorders, Pain And Epilepsy Cause Psychiatric Disorders Later In Life?

Date:
October 25, 2009
Source:
Georgetown University Medical Center
Summary:
Young animals treated with commonly-prescribed drugs develop behavioral abnormalities in adulthood say researchers. The drugs tested include those used to treat epilepsy, mood disorders and pain.

Young animals treated with commonly-prescribed drugs develop behavioral abnormalities in adulthood say researchers at Georgetown University Medical Center. The drugs tested include those used to treat epilepsy, mood disorders and pain.

GUMC neuroscientists and others have previously shown that neurons die after these drugs are administered to immature preclinical animal models. They say the regions of the brain where this drug-induced cell death takes place are important in the regulation of mood, cognition, and movement. In the research presented at the 39th annual meeting of the Society for Neuroscience, the scientists examined if behavioral function would be affected by the drugs.

Using behavioral tests to detect characteristics of autism and schizophrenia, the researchers found that when given to infant rats, the drugs caused behavioral abnormalities later in life. What's more, the abnormalities were not limited to the drugs known to cause neuronal cell death.

"That is of particular concern because some of the drugs may predispose to psychiatric disorders later in life," says lead author Patrick Forcelli, a graduate student in the Interdisciplinary Program in Neuroscience at GUMC. "At the same time, our studies identify specific drugs that cause little or no long-term behavioral impairment." Forcelli says additional research will help physicians to better select drugs to treat epilepsy, mood disorders or pain in infants and pregnant women.

The study was funded by grants from the National Institutes of Health and with a research award from GlaxoSmithKline and a Fellowship from the Epilepsy Foundation. The authors report no related financial interests.


Story Source:

The above story is based on materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Georgetown University Medical Center. "Could Drugs For Mood Disorders, Pain And Epilepsy Cause Psychiatric Disorders Later In Life?." ScienceDaily. ScienceDaily, 25 October 2009. <www.sciencedaily.com/releases/2009/10/091020161952.htm>.
Georgetown University Medical Center. (2009, October 25). Could Drugs For Mood Disorders, Pain And Epilepsy Cause Psychiatric Disorders Later In Life?. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2009/10/091020161952.htm
Georgetown University Medical Center. "Could Drugs For Mood Disorders, Pain And Epilepsy Cause Psychiatric Disorders Later In Life?." ScienceDaily. www.sciencedaily.com/releases/2009/10/091020161952.htm (accessed October 2, 2014).

Share This



More Mind & Brain News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Stopping School Violence

Stopping School Violence

Ivanhoe (Oct. 1, 2014) A trauma doctor steps out of the hospital and into the classroom to teach kids how to calmly solve conflicts, avoiding a trip to the ER. Video provided by Ivanhoe
Powered by NewsLook.com
Pineal Cysts: Debilitating Pain

Pineal Cysts: Debilitating Pain

Ivanhoe (Oct. 1, 2014) A tiny cyst in the brain that can cause debilitating symptoms like chronic headaches and insomnia, and the doctor who performs the delicate surgery to remove them. Video provided by Ivanhoe
Powered by NewsLook.com
Burning Away Brain Tumors

Burning Away Brain Tumors

Ivanhoe (Oct. 1, 2014) Doctors are 'cooking' brain tumors. Hear how this new laser-heat procedure cuts down on recovery time. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins