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Treatment For Epilepsy Is Possible Culprit For Development Of Schizophrenia

Date:
October 24, 2009
Source:
Georgetown University Medical Center
Summary:
Researchers say antiepilectic drug treatments administered when the brain is developing appear to trigger schizophrenia-like behavior in animal models. In humans, having a history of seizures in infancy is a significant risk factor for development of schizophrenia later in life, but it is not known whether the elevated risk is due to seizures themselves, or from side effects antiepileptic drug treatment.
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Researchers say antiepilectic drug treatments administered when the brain is developing appear to trigger schizophrenia-like behavior in animal models. In humans, having a history of seizures in infancy is a significant risk factor for development of schizophrenia later in life, but it is not known whether the elevated risk is due to seizures themselves, or from side effects antiepileptic drug (AED) treatment.

In research presented at the 39th annual meeting of the Society for Neuroscience, Georgetown University Medical Center researchers show that exposure to AEDs during critical periods of brain development in animal models increases schizophrenia-like behaviors.

"We know that early-life exposure to AEDs such as Phenobarbital triggers cell death in many brain regions associated with the onset of schizophrenia," explains Guillermo Palchik, a doctoral student in the department of pediatrics at GUMC. "This study not only suggests a relationship between the drugs and schizophrenia, but it raises important questions regarding the side effects of a widely-used class of drugs. Phenobarbital and other AEDs are not only used as a treatment for seizures but more generally in the treatment of migraines, neuropathic pain and mood disorders, among other ailments, and can be considered drugs of abuse."

The study was funded by grants from the National Institutes of Health and a research award from GlaxoSmithKline. The authors report no related financial interests.


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The above post is reprinted from materials provided by Georgetown University Medical Center. Note: Materials may be edited for content and length.


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Georgetown University Medical Center. "Treatment For Epilepsy Is Possible Culprit For Development Of Schizophrenia." ScienceDaily. ScienceDaily, 24 October 2009. <www.sciencedaily.com/releases/2009/10/091020161954.htm>.
Georgetown University Medical Center. (2009, October 24). Treatment For Epilepsy Is Possible Culprit For Development Of Schizophrenia. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/2009/10/091020161954.htm
Georgetown University Medical Center. "Treatment For Epilepsy Is Possible Culprit For Development Of Schizophrenia." ScienceDaily. www.sciencedaily.com/releases/2009/10/091020161954.htm (accessed September 1, 2015).

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