Featured Research

from universities, journals, and other organizations

Eosinophils In Allergy And Asthma

Date:
November 3, 2009
Source:
American Journal of Pathology
Summary:
Researchers have discovered that eosinophils may play a pivotal role in immune development.

Researchers led by Dr. Redwan Moqbel at the University of Alberta, University of Western Australian, and Princess Margaret Hospital in Perth, Australia have discovered that eosinophils may play a pivotal role in immune development. These results are presented in the November 2009 issue of The American Journal of Pathology.

Related Articles


Asthma and allergic disease occur when the immune system improperly responds to harmless environmental substances such as pollen or mold. Common allergic reactions include eczema, hives, hay fever, asthma, food allergies, and reactions to the venom of stinging insects such as wasps and bees.

Immune responses can be classified as Th1 or Th2 based on the type of inflammation and molecules secreted after stimulation. Th1 immune responses traditionally fight intracellular infections such as bacterial and viral infections, whereas Th2 responses are specialized for large parasites such as worms. Asthma and allergic disease result from an improper Th2 immune response.

Although eosinophils, a type of immune cell, have long been considered to mediate allergic and asthmatic Th2 immune responses, they may also play a role in determining the switch between Th1 and Th2 immune responses. Tulic et al therefore examined the development of eosinophils in human children. They observed an age-dependent decrease in the number of eosinophils in the thymus, an organ where early Th1/Th2 differentiation may occur, suggesting an early role of eosinophils in Th2 bias.

Dr. Moqbel's group suggests that "functional thymic IDO+ eosinophils during human infant life may have an immunomodulatory role in Th2 immune responses."


Story Source:

The above story is based on materials provided by American Journal of Pathology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tulic MK, Sly PD, Andrews D, Crook M, Davoine F, Odemuyiwa SO, Charles A, Hodder ML, Prescott SL, Holt PG, Moqbel R. Thymic Indoleamine 2,3-Dioxygenase Positive Eosinophils in Young Children. Potential Role In Maturation Of The Naive Immune System. American Journal Of Pathology, 2009; DOI: 10.2353/ajpath.2009.090015

Cite This Page:

American Journal of Pathology. "Eosinophils In Allergy And Asthma." ScienceDaily. ScienceDaily, 3 November 2009. <www.sciencedaily.com/releases/2009/10/091022071357.htm>.
American Journal of Pathology. (2009, November 3). Eosinophils In Allergy And Asthma. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2009/10/091022071357.htm
American Journal of Pathology. "Eosinophils In Allergy And Asthma." ScienceDaily. www.sciencedaily.com/releases/2009/10/091022071357.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins