Featured Research

from universities, journals, and other organizations

How Low Doses Of Radiation Can Cause Heart Disease And Stroke

Date:
October 23, 2009
Source:
Public Library of Science
Summary:
A mathematical model constructed by researchers predicts the risk of cardiovascular disease (heart attacks, stroke) associated with low background levels of radiation. The model shows that the risk would vary almost in proportion with dose. Results are consistent with risk levels reported in previous studies involving nuclear workers.

A mathematical model constructed by researchers at Imperial College London predicts the risk of cardiovascular disease (heart attacks, stroke) associated with low background levels of radiation. The model shows that the risk would vary almost in proportion with dose.

Related Articles


Results, published October 23 in the open-access journal PLoS Computational Biology, are consistent with risk levels reported in previous studies involving nuclear workers.

Cardiovascular disease is the leading cause of death and one of the leading causes of disability in developed countries, as reported in the paper and also by the World Health Organization. For some time, scientists have understood how high-dose radiotherapy (RT) causes inflammation in the heart and large arteries and how this results in the increased levels of cardiovascular disease observed in many groups of patients who receive RT. However, in the last few years, studies have shown that there may also be cardiovascular risks associated with the much lower fractionated doses of radiation received by groups such as nuclear workers, but it is not clear what biological mechanisms are responsible.

The Imperial College London team, led by Dr. Mark Little, has explored a novel mechanism that suggests that radiation kills monocytes (a type of white blood cell) in the arterial wall, which would otherwise bind to monocyte chemo-attractant protein 1 (MCP-1). The resultant higher levels of MCP-1 cause inflammation which leads to cardiovascular disease. As well as being consistent with what is seen in nuclear workers, the changes in MCP-1 caused by dietary cholesterol that are predicted by the model are also consistent with experimental and epidemiologic data.

If the mechanism is valid it implies that risks from low dose radiation exposures (e.g., medical and dental X-rays), which until now have been assumed to result only from cancer, may have been substantially underestimated, say the authors.

The biological mechanism has yet to be experimentally tested. Further research is planned to investigate this.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Little MP, Gola A, Tzoulaki I. A Model of Cardiovascular Disease Giving a Plausible Mechanism for the Effect of Fractionated Low-Dose Ionizing Radiation Exposure. PLoS Computational Biology, 2009; 5 (10): e1000539 DOI: 10.1371/journal.pcbi.1000539

Cite This Page:

Public Library of Science. "How Low Doses Of Radiation Can Cause Heart Disease And Stroke." ScienceDaily. ScienceDaily, 23 October 2009. <www.sciencedaily.com/releases/2009/10/091022202710.htm>.
Public Library of Science. (2009, October 23). How Low Doses Of Radiation Can Cause Heart Disease And Stroke. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/10/091022202710.htm
Public Library of Science. "How Low Doses Of Radiation Can Cause Heart Disease And Stroke." ScienceDaily. www.sciencedaily.com/releases/2009/10/091022202710.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins