Featured Research

from universities, journals, and other organizations

How Low Doses Of Radiation Can Cause Heart Disease And Stroke

Date:
October 23, 2009
Source:
Public Library of Science
Summary:
A mathematical model constructed by researchers predicts the risk of cardiovascular disease (heart attacks, stroke) associated with low background levels of radiation. The model shows that the risk would vary almost in proportion with dose. Results are consistent with risk levels reported in previous studies involving nuclear workers.

A mathematical model constructed by researchers at Imperial College London predicts the risk of cardiovascular disease (heart attacks, stroke) associated with low background levels of radiation. The model shows that the risk would vary almost in proportion with dose.

Related Articles


Results, published October 23 in the open-access journal PLoS Computational Biology, are consistent with risk levels reported in previous studies involving nuclear workers.

Cardiovascular disease is the leading cause of death and one of the leading causes of disability in developed countries, as reported in the paper and also by the World Health Organization. For some time, scientists have understood how high-dose radiotherapy (RT) causes inflammation in the heart and large arteries and how this results in the increased levels of cardiovascular disease observed in many groups of patients who receive RT. However, in the last few years, studies have shown that there may also be cardiovascular risks associated with the much lower fractionated doses of radiation received by groups such as nuclear workers, but it is not clear what biological mechanisms are responsible.

The Imperial College London team, led by Dr. Mark Little, has explored a novel mechanism that suggests that radiation kills monocytes (a type of white blood cell) in the arterial wall, which would otherwise bind to monocyte chemo-attractant protein 1 (MCP-1). The resultant higher levels of MCP-1 cause inflammation which leads to cardiovascular disease. As well as being consistent with what is seen in nuclear workers, the changes in MCP-1 caused by dietary cholesterol that are predicted by the model are also consistent with experimental and epidemiologic data.

If the mechanism is valid it implies that risks from low dose radiation exposures (e.g., medical and dental X-rays), which until now have been assumed to result only from cancer, may have been substantially underestimated, say the authors.

The biological mechanism has yet to be experimentally tested. Further research is planned to investigate this.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Little MP, Gola A, Tzoulaki I. A Model of Cardiovascular Disease Giving a Plausible Mechanism for the Effect of Fractionated Low-Dose Ionizing Radiation Exposure. PLoS Computational Biology, 2009; 5 (10): e1000539 DOI: 10.1371/journal.pcbi.1000539

Cite This Page:

Public Library of Science. "How Low Doses Of Radiation Can Cause Heart Disease And Stroke." ScienceDaily. ScienceDaily, 23 October 2009. <www.sciencedaily.com/releases/2009/10/091022202710.htm>.
Public Library of Science. (2009, October 23). How Low Doses Of Radiation Can Cause Heart Disease And Stroke. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/10/091022202710.htm
Public Library of Science. "How Low Doses Of Radiation Can Cause Heart Disease And Stroke." ScienceDaily. www.sciencedaily.com/releases/2009/10/091022202710.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins