Featured Research

from universities, journals, and other organizations

Cigarette Smoke May Impair Lungs Natural Defense Against Harmful Pathogen

Date:
October 26, 2009
Source:
American Society for Microbiology
Summary:
Exposure to cigarette smoke may impair the ability of immune cells to clear bacterial infections from the lungs, specifically nontypeable Haemophilus influenzae (NTHI), a pathogen often associated with respiratory infections and the progression of respiratory diseases.

Exposure to cigarette smoke may impair the ability of immune cells to clear bacterial infections from the lungs, specifically nontypeable Haemophilus influenzae (NTHI), a pathogen often associated with respiratory infections and the progression of respiratory diseases.

The researchers from Spain and the United Kingdom report their findings in the October 2009 issue of the journal Infection and Immunity.

NTHI, commonly found in the human respiratory tract, may remain asymptomatic in healthy individuals or it can cause invasive diseases such as meningitis, sinusitis, pneumonia, and bronchitis. It is also the pathogen most frequently isolated in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Alveolar macrophages are part of the lungs' innate defense system and they play an essential role in the clearance of bacterial infections. Prior associations between cigarette smoke and respiratory infections caused by NTHI have been established and now researchers are hypothesizing that cigarette smoke may disrupt the capability of alveolar macrophages to clear NTHI from the lungs.

In the study researchers first examined the interaction between NTHI and alveolar macrophages and found that the macrophages adhere to and ingest NTHI, a process known as phagocytosis. Researchers also observed the effect of cigarette smoke in macrophage cell lines and human alveolar macrophages obtained from smokers and patients with COPD and found that cigarette smoke extract impaired the alveolar macrophage process. Additionally, cells exposed to cigarette smoke extract were treated with glucocorticoid, an anti-inflammatory drug commonly used to treat respiratory conditions, and results showed that the drug did not compensate for the impairment to the alveolar macrophage process caused by the cigarette smoke.

"This study revealed novel effects of cigarette smoking on alveolar macrophage physiological functions which could contribute to lung bacterial colonization by opportunistic pathogens, such as NTHI," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Marti-Lliteras, V. Regueiro, P. Morey, D.W. Hood, C. Saus, J. Sauleda, A.G.N. Agusti, J.A. Bengoechea, J. Garmendia. Nontypeable Haemophilus influenzae Clearance by Alveolar Macrophages Is Impaired by Exposure to Cigarette Smoke. Infection and Immunity, 2009; 77 (10): 4232 DOI: 10.1128/IAI.00305-09

Cite This Page:

American Society for Microbiology. "Cigarette Smoke May Impair Lungs Natural Defense Against Harmful Pathogen." ScienceDaily. ScienceDaily, 26 October 2009. <www.sciencedaily.com/releases/2009/10/091025200317.htm>.
American Society for Microbiology. (2009, October 26). Cigarette Smoke May Impair Lungs Natural Defense Against Harmful Pathogen. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2009/10/091025200317.htm
American Society for Microbiology. "Cigarette Smoke May Impair Lungs Natural Defense Against Harmful Pathogen." ScienceDaily. www.sciencedaily.com/releases/2009/10/091025200317.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins