Featured Research

from universities, journals, and other organizations

Chemosensitivity Of Cancer Cells Depends On Their Protein Dependency

Date:
October 26, 2009
Source:
Rockefeller University Press
Summary:
Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, researchers report.

The spleen of mice overexpressing the oncogene c-myc and the anti-apoptotic protein MCL-1 is crowded with leukemia cells.
Credit: Brunelle, J.K., et al. 2009. J. Cell Biol. doi:10.1083/jcb.200904049

Two different anti-apoptotic proteins support cancer cell survival via an identical mechanism, yet differ in their sensitivity to chemotherapeutic drugs, report Brunelle et al. The study will be published online October 26, 2009 and in the November 2, 2009 print issue of the Journal of Cell Biology (JCB).

Related Articles


Cancer cells often become dependent on one or more anti-apoptotic proteins to avoid death while continuing to proliferate. BCL-2, for example, is overexpressed in many cancers and mops up pro-apoptotic proteins to prevent them from permeabilizing mitochondria and initiating cell death. Other tumors are reliant on a related protein called MCL-1, but less is known about this member of the BCL-2 family. Brunelle et al. created leukemic mice overexpressing MCL-1 and compared them to similar mice that produced excess BCL-2.

The leukemias suffered by these two types of mice were identical, yet a technique called BH3 profiling was able to distinguish between cells derived from the different animals by demonstrating a dependency on one or other of the two anti-apoptotic proteins. Immunoprecipitation experiments revealed that MCL-1 and BCL-2 both work by sequestering the same two pro-apoptotic targets. Surprisingly then, leukemia cells reliant on MCL-1 were much more sensitive to a range of chemotherapeutic drugs than their BCL-2-dependent counterparts were. Brunelle et al. found that the different cytotoxic drugs all caused a rapid decrease in MCL-1 protein levels via proteosome-mediated degradation, allowing cell death to proceed quickly. BCL-2 protein is more stable however, so additional time and more drug is needed to kill BCL-2-dependent cancer cells.

Thus, the block in apoptosis selected during oncogenesis is not necessarily complete, and can have a major influence on the cancer's chemosensitivity. Senior author Anthony Letai now plans to use BH3 profiling on human tumors, to determine which anti-apoptotic protein a patient's cancer is dependent on and to correlate this with the tumor's response to chemotherapy.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brunelle et al. MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts. The Journal of Cell Biology, 2009; DOI: 10.1083/jcb.200904049

Cite This Page:

Rockefeller University Press. "Chemosensitivity Of Cancer Cells Depends On Their Protein Dependency." ScienceDaily. ScienceDaily, 26 October 2009. <www.sciencedaily.com/releases/2009/10/091026093712.htm>.
Rockefeller University Press. (2009, October 26). Chemosensitivity Of Cancer Cells Depends On Their Protein Dependency. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2009/10/091026093712.htm
Rockefeller University Press. "Chemosensitivity Of Cancer Cells Depends On Their Protein Dependency." ScienceDaily. www.sciencedaily.com/releases/2009/10/091026093712.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins