Featured Research

from universities, journals, and other organizations

New Light On The SARS Virus

Date:
November 10, 2009
Source:
NWO (Netherlands Organization for Scientific Research)
Summary:
Using novel techniques, a Dutch researcher has cast new light on the replication of coronaviruses, a family of viruses including the cause of SARS. He has shown, using luminescent viruses, how coronaviruses use host cells and how we can use the intracellular processes to attack the virus.

Using novel techniques, Dutch researcher Matthijs Raaben has cast new light on the replication of coronaviruses, a family of viruses including the cause of SARS. He has shown, using luminescent viruses, how coronaviruses use host cells and how we can use the intracellular processes to attack the virus.

Coronaviruses are entirely dependent, for their replication and dissemination, on the cells they infect. Using microchips, Raaben has successfully investigated various processes involving the mouse hepatitis coronavirus (MHV) in a cell. His discoveries included a finding that the proliferation of MHV can be restrained by blocking the proteasome of a cell, the mechanism that deals with cleaning out surplus proteins. Restricting this clean-up action may also combat infections from the coronavirus in living animals. Attacking the virus at the level of the host cells may be a better way of avoiding an increase in resistance to antiviral medicines. This is because the treatment does not attack the virus directly, but rather the processes in the cell that the virus needs in order to replicate itself.

Luminescent viruses

Raaben used microchips for his research, but also a new technique -- bioluminescence imaging -- to track the virus in a living organism. He arranged for the virus to start producing a luminescent protein, derived from a firefly. This light could then be detected using an extremely light-sensitive camera, allowing the spread of the virus to be monitored closely. The major benefit of this is that only one mouse is needed for research into different phases of a virus infection, instead of a different mouse for each phase.

Coronaviruses are known to be the cause of respiratory tract and intestinal infections in various types of animals such as chickens, cats and pigs. In 2003, however, it transpired that a coronavirus was also the cause of SARS, an illness that has since claimed the lives of more than 800 human victims. We need to know more about this group of viruses in order to be in a better position to combat any new outbreaks of SARS or other coronaviruses.

Raaben's research into the interactions taking place between coronaviruses and the host is part of the project headed by Vidi prizewinner Xander de Haan.


Story Source:

The above story is based on materials provided by NWO (Netherlands Organization for Scientific Research). Note: Materials may be edited for content and length.


Cite This Page:

NWO (Netherlands Organization for Scientific Research). "New Light On The SARS Virus." ScienceDaily. ScienceDaily, 10 November 2009. <www.sciencedaily.com/releases/2009/10/091029151449.htm>.
NWO (Netherlands Organization for Scientific Research). (2009, November 10). New Light On The SARS Virus. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2009/10/091029151449.htm
NWO (Netherlands Organization for Scientific Research). "New Light On The SARS Virus." ScienceDaily. www.sciencedaily.com/releases/2009/10/091029151449.htm (accessed April 18, 2014).

Share This



More Plants & Animals News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Great British Farmland Boom

The Great British Farmland Boom

Reuters - Business Video Online (Apr. 17, 2014) Britain's troubled Co-operative Group is preparing to cash in on nearly 18,000 acres of farmland in one of the biggest UK land sales in decades. As Ivor Bennett reports, the market timing couldn't be better, with farmland prices soaring over 270 percent in the last 10 years. Video provided by Reuters
Powered by NewsLook.com
Flamingo Frenzy Ahead of Zoo Construction

Flamingo Frenzy Ahead of Zoo Construction

AP (Apr. 17, 2014) With plenty of honking, flapping, and fluttering, more than three dozen Caribbean flamingos at Zoo Miami were rounded up today as the iconic exhibit was closed for renovations. (April 17) Video provided by AP
Powered by NewsLook.com
Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins