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Inappropriate sepsis therapy leads to fivefold reduction in survival

Date:
November 16, 2009
Source:
American College of Chest Physicians
Summary:
New research shows that patients with septic shock may have a fivefold reduction in survival.

Patients experiencing septic shock who receive inappropriate therapy may have a fivefold reduction in survival, shows a new study. Researchers from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the cases of 5,715 patients with septic shock to determine the appropriateness of initial antimicrobial therapy, clinical infection site, and relevant pathogens.

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Results showed that inappropriate initial antimicrobial therapy occurred in 20 percent of patients, and the overall survival was 43.7 percent. Survival after appropriate and inappropriate initial therapy was 52 percent and 10.3 percent, respectively.

Furthermore, the decrease in survival with inappropriate initial therapy ranged from 2.3-fold for pneumococcal infection to 17.6-fold with primary bacteremia. Researchers conclude that efforts to increase the frequency of appropriateness of initial antimicrobial therapy must be central to efforts to reduce mortality from septic shock.

The article is published in the November issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians.


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The above story is based on materials provided by American College of Chest Physicians. Note: Materials may be edited for content and length.


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American College of Chest Physicians. "Inappropriate sepsis therapy leads to fivefold reduction in survival." ScienceDaily. ScienceDaily, 16 November 2009. <www.sciencedaily.com/releases/2009/11/091105084846.htm>.
American College of Chest Physicians. (2009, November 16). Inappropriate sepsis therapy leads to fivefold reduction in survival. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2009/11/091105084846.htm
American College of Chest Physicians. "Inappropriate sepsis therapy leads to fivefold reduction in survival." ScienceDaily. www.sciencedaily.com/releases/2009/11/091105084846.htm (accessed February 28, 2015).

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