Featured Research

from universities, journals, and other organizations

Key Player Identified In Cascade That Leads To Hypertension-related Kidney Damage

Date:
November 5, 2009
Source:
Medical College of Georgia
Summary:
A key player in a cascade that likely begins with stress and leads to high blood pressure and kidney damage has been identified by researchers who say the finding may lead to better ways to control both. Medical researchers have found endothelin, a powerful blood vessel constrictor and inflammatory peptide, increases the number of T cells in the kidneys, which helps recruit other immune cells, causing inflammation and destruction.

A key player in a cascade that likely begins with stress and leads to high blood pressure and kidney damage has been identified by researchers who say the finding may lead to better ways to control both.

Related Articles


Medical College of Georgia researchers have found endothelin, a powerful blood vessel constrictor and inflammatory peptide, increases the number of T cells in the kidneys, which helps recruit other immune cells, causing inflammation and destruction.

"We think that endothelin somehow causes an increase in T cells which results in renal injury which makes the hypertension worse and harder to control," says Dr. Karthik Krishnan, an MCG allergy/immunology fellow who presents the findings during the 2009 American College of Allergy, Asthma & Immunology Annual Meeting Nov. 5-9 in Miami.Dr. Krishnan was honored with one of three Clement von Pirquet Awards for best scientific paper in allergy/immunology presented by fellows-in-training at the meeting.

The process likely begins in some people when stress, diet or other factors raise levels of the hormone angiotensin II, another powerful blood vessel constrictor, which, in turn, increases endothelin levels. Researchers don't know why endothelin increases T-cell levels in the kidneys. "There are still a lot of mechanistic questions we have," notes Dr. Krishnan.

Inflammation, a part of the normal healing process, also is increasingly identified as a major contributor to a variety of diseases from cancer to cardiovascular disease. "We are starting to look at inflammatory mediators or processes that make hypertension worse with the long-term goal of finding interventions or therapies to counteract these mediators and better control hypertension and prevent organ damage," Dr. Krishnan says.

It's a subset of patients -- with mostly uncontrolled hypertension, likely because of a combination of environment and genetics -- that tend to have more inflammation and more resulting kidney damage. Dr. Krishnan hopes that making the endothelin connection will one day help identify these people before their kidneys take a beating.

Standard urinalysis can detect protein in the urine, one of the first signs sign that "the kidneys are falling down on the job," says Dr. David Pollock, renal physiologist in MCG's Vascular Biology Center and a study co-author. "It's like a cheesecloth that is old and worn out and the holes are getting too big." The body should use all the protein it makes or consumes so none should show up in urine

For the study, mice with normal blood pressures got angiotensin II, which raised their blood pressure and the T cell count in their kidneys. But when researchers also gave an endothelin blocker, T cells numbers in the kidneys did not increase. To double-check the findings, they gave angiotensin II to mice that can't make endothelin and the T cell count stayed down, the researchers report.

For at-risk individuals, endothelin blockers, already on the market for pulmonary hypertension and under study for some other conditions that result in kidney failure, may help avoid the destruction, Dr. Pollock says.

"We're optimistic that it's important in other forms of renal disease. It looks like this could be useful for essentially anyone with protein in the urine. That's what's really exciting about it," he says.


Story Source:

The above story is based on materials provided by Medical College of Georgia. Note: Materials may be edited for content and length.


Cite This Page:

Medical College of Georgia. "Key Player Identified In Cascade That Leads To Hypertension-related Kidney Damage." ScienceDaily. ScienceDaily, 5 November 2009. <www.sciencedaily.com/releases/2009/11/091105102733.htm>.
Medical College of Georgia. (2009, November 5). Key Player Identified In Cascade That Leads To Hypertension-related Kidney Damage. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2009/11/091105102733.htm
Medical College of Georgia. "Key Player Identified In Cascade That Leads To Hypertension-related Kidney Damage." ScienceDaily. www.sciencedaily.com/releases/2009/11/091105102733.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins