Featured Research

from universities, journals, and other organizations

Polycystins: Proteins That Regulate The Cellular Barometer

Date:
November 6, 2009
Source:
CNRS
Summary:
What is the role of proteins called polycystins in patients with polycystic kidney disease? Scientists have elucidated the molecular and cellular mechanisms linked to polycystin malfunctions that cause this common hereditary disease.

The role of polycystins in regulating the cellular barometer, or how ion channels allow cells to perceive membrane stretching.
Credit: Copyright Eric Honoré / IPMC

What is the role of proteins called polycystins in patients with polycystic kidney disease? A team of researchers from CNRS and INSERM, led by Eric Honoré from the Institut de Pharmacologie Moléculaire et Cellulaire (IPMC, Université de Nice Sophia Antipolis/CNRS) has elucidated the molecular and cellular mechanisms linked to polycystin malfunctions that cause this common hereditary disease.

Related Articles


In a study published on October 30, 2009 in the journal Cell, Honoré and his colleagues reveal a new biological function for polycystins in regulating pressure sensing.

Adult polycystic kidney disease is a genetic condition that affects about 60,000 people each year in France and for which there is currently no drug therapy. Hypertension is very often the symptom that reveals the presence of this disease, which is characterized by the development of renal, hepatic and pancreatic cysts. Polycystic disease thus affects the kidneys but also other organs, and particularly the cardiovascular system. Indeed, sufferers present with arterial fragility. Although this disease is responsible for 10% of cases of terminal renal failure, the most dangerous complication is linked to the development of intracranial aneurysms that can cause fatal cerebral hemorrhage.

This disease is linked to a malfunction of polycystin proteins 1 and 2 (coded by two genes, PKD1 and PKD2). At the IPMC, CNRS and INSERM scientists led by Eric Honoré have discovered the pivotal role of polycystins in sensing cell pressure. Indeed, they have demonstrated that polycystins 1 and 2 control cell sensitivity to membrane stretching. These proteins, inserted in the cellular plasma membrane, form an ion channel that allows the passage of calcium ions. Because of a genetic mutation that affects the kidneys of polycystic patients, the channels formed by polycystins do not open correctly; calcium fluxes are reduced, triggering cell proliferation and the formation of cysts. It is the ratio between polycystins 1 and 2 that controls this cellular barometer. The inactivation of polycystin 1 in mouse smooth muscle (a vessel wall constituent) caused an inhibition of pressure sensitivity and consequently a drop in vascular tone.

This new biological function for polycystins as a regulator of cellular pressure enables a clearer understanding of the molecular mechanisms underlying the mechanosensitivity of cells. This work has also contributed to elucidating the pathophysiological role of polycystins, and may make it possible to envisage novel therapeutic strategies for the treatment of polycystic kidney disease.


Story Source:

The above story is based on materials provided by CNRS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sharif-Naeini et al. Polycystin-1 and -2 Dosage Regulates Pressure Sensing. Cell, 2009; 139 (3): 587 DOI: 10.1016/j.cell.2009.08.045

Cite This Page:

CNRS. "Polycystins: Proteins That Regulate The Cellular Barometer." ScienceDaily. ScienceDaily, 6 November 2009. <www.sciencedaily.com/releases/2009/11/091106102548.htm>.
CNRS. (2009, November 6). Polycystins: Proteins That Regulate The Cellular Barometer. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2009/11/091106102548.htm
CNRS. "Polycystins: Proteins That Regulate The Cellular Barometer." ScienceDaily. www.sciencedaily.com/releases/2009/11/091106102548.htm (accessed October 31, 2014).

Share This



More Plants & Animals News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Watch Baby Goose Survive A 400-Foot Cliff Dive

Watch Baby Goose Survive A 400-Foot Cliff Dive

Buzz60 (Oct. 31, 2014) — For its nature series Life Story, the BBC profiled the barnacle goose, whose chicks must make a daredevil 400-foot cliff dive from their nests to find food. Jen Markham has the astonishing video. Video provided by Buzz60
Powered by NewsLook.com
World's Salamanders At Risk From Flesh-Eating Fungus

World's Salamanders At Risk From Flesh-Eating Fungus

Newsy (Oct. 31, 2014) — The import of salamanders around the globe is thought to be contributing to the spread of a deadly fungus. Video provided by Newsy
Powered by NewsLook.com
Alcoholic Drinks In The E.U. Could Get Calorie Labels

Alcoholic Drinks In The E.U. Could Get Calorie Labels

Newsy (Oct. 31, 2014) — A health group in the United Kingdom has called for mandatory calorie labels on alcoholic beverages in the European Union. Video provided by Newsy
Powered by NewsLook.com
Malaria Threat in Liberia as Fight Against Ebola Rages

Malaria Threat in Liberia as Fight Against Ebola Rages

AFP (Oct. 31, 2014) — Focus on treating the Ebola epidemic in Liberia means that treatment for malaria, itself a killer, is hard to come by. MSF are now undertaking the mass distribution of antimalarials in Monrovia. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins