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Toward explaining why hepatitis B hits men harder than women

Date:
November 24, 2009
Source:
American Chemical Society
Summary:
Scientists have discovered unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus sexually discriminates -- hitting men harder than women.

These are hepatitis B particles as viewed under an electron microscope.
Credit: US Centers for Disease Control

Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.

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Shuhan Sun, Fang Wang and colleagues note that chronic hepatitis B seems to progress and cause liver damage faster in men, with men the main victims of the virus's most serious complications -- cirrhosis and liver cancer. Men infected with HBV also are 6 times more likely than women to develop a chronic form of the disease. About 400 million people worldwide have chronic hepatitis B, including a form that is highly infectious and can be transmitted through blood, saliva, and sexual contact.

In experiments with laboratory mice, the scientists found abnormal forms of apolipoprotein A-I (Apo A-I), a protein involved in fighting inflammation, in the livers of infected male mice but not infected females. They then identified abnormal forms of these Apo A-I proteins in blood of men infected with HBV, but not in women. In addition to explaining the gender differences, the proteins may provide important markers for tracking the progression of hepatitis B, the scientists suggest.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yang et al. An Altered Pattern of Liver Apolipoprotein A-I Isoforms Is Implicated in Male Chronic Hepatitis B Progression. Journal of Proteome Research, 2009; 091008145148093 DOI: 10.1021/pr900593r

Cite This Page:

American Chemical Society. "Toward explaining why hepatitis B hits men harder than women." ScienceDaily. ScienceDaily, 24 November 2009. <www.sciencedaily.com/releases/2009/11/091118112425.htm>.
American Chemical Society. (2009, November 24). Toward explaining why hepatitis B hits men harder than women. ScienceDaily. Retrieved March 4, 2015 from www.sciencedaily.com/releases/2009/11/091118112425.htm
American Chemical Society. "Toward explaining why hepatitis B hits men harder than women." ScienceDaily. www.sciencedaily.com/releases/2009/11/091118112425.htm (accessed March 4, 2015).

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