Featured Research

from universities, journals, and other organizations

Sticky solution for identifying effective probiotics

Date:
November 25, 2009
Source:
Norwich BioScience Institutes
Summary:
Scientists have crystallized a protein that may help gut bacteria bind to the gastrointestinal tract. The protein could be used by probiotic producers to identify strains that are likely to be of real benefit to people.

Scientists have crystallised a protein that may help gut bacteria bind to the gastrointestinal tract. The protein could be used by probiotic producers to identify strains that are likely to be of real benefit to people.

"Probiotics need to interact with cells lining the gut to have a beneficial effect, and if they attach to surfaces in the gut they are more likely to stick around long enough to exert their activity," says Dr Nathalie Juge from the Institute of Food Research. IFR is an Institute of the Biotechnology and Biological Sciences Research Council, which funded the research.

The gut is the largest immune system organ in the body. The cells lining the gut are covered in a protective layer of mucus that is continuously renewed by specialised cells. As well as protecting the gut lining, mucus provides an attachment site for beneficial bacteria that help maintain normal gut function.

Mucus adhesion has been well studied for pathogenic bacteria, but precisely what enables commensal (our gut bacteria) bacteria to stick is not known. In a paper published in the Journal of Biological Chemistry, IFR and University of East Anglia scientists have obtained the first crystal structure of a mucus-binding protein.

The protein was obtained from a strain of Lactobacillus reuteri, a lactic acid bacterium naturally found in the gastrointestinal tract. Lactic acid bacteria are the most common microorganisms used as probiotics.

These mucus-binding proteins are more abundant in lactic acid bacteria than other types and particularly in strains that inhabit the gut. The presence of the proteins may contribute to the ability of lactic acid bacteria to interact with the host.

The team of scientists found that these mucus-binding proteins also recognise human immunoglobulin proteins. These are an integral part of the immune system. Mucus-binding proteins may therefore also play a wider role in gut health as a site of attachment for bacteria.

"The strain-specificity of these proteins demonstrates the need for the careful molecular design and selection of probiotics," says Dr Juge. "This also opens new avenues of research to study the fundamental roles bacteria play in the gastrointestinal tract."


Story Source:

The above story is based on materials provided by Norwich BioScience Institutes. Note: Materials may be edited for content and length.


Cite This Page:

Norwich BioScience Institutes. "Sticky solution for identifying effective probiotics." ScienceDaily. ScienceDaily, 25 November 2009. <www.sciencedaily.com/releases/2009/11/091124113611.htm>.
Norwich BioScience Institutes. (2009, November 25). Sticky solution for identifying effective probiotics. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2009/11/091124113611.htm
Norwich BioScience Institutes. "Sticky solution for identifying effective probiotics." ScienceDaily. www.sciencedaily.com/releases/2009/11/091124113611.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins