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Sticky solution for identifying effective probiotics

Date:
November 25, 2009
Source:
Norwich BioScience Institutes
Summary:
Scientists have crystallized a protein that may help gut bacteria bind to the gastrointestinal tract. The protein could be used by probiotic producers to identify strains that are likely to be of real benefit to people.

Scientists have crystallised a protein that may help gut bacteria bind to the gastrointestinal tract. The protein could be used by probiotic producers to identify strains that are likely to be of real benefit to people.

"Probiotics need to interact with cells lining the gut to have a beneficial effect, and if they attach to surfaces in the gut they are more likely to stick around long enough to exert their activity," says Dr Nathalie Juge from the Institute of Food Research. IFR is an Institute of the Biotechnology and Biological Sciences Research Council, which funded the research.

The gut is the largest immune system organ in the body. The cells lining the gut are covered in a protective layer of mucus that is continuously renewed by specialised cells. As well as protecting the gut lining, mucus provides an attachment site for beneficial bacteria that help maintain normal gut function.

Mucus adhesion has been well studied for pathogenic bacteria, but precisely what enables commensal (our gut bacteria) bacteria to stick is not known. In a paper published in the Journal of Biological Chemistry, IFR and University of East Anglia scientists have obtained the first crystal structure of a mucus-binding protein.

The protein was obtained from a strain of Lactobacillus reuteri, a lactic acid bacterium naturally found in the gastrointestinal tract. Lactic acid bacteria are the most common microorganisms used as probiotics.

These mucus-binding proteins are more abundant in lactic acid bacteria than other types and particularly in strains that inhabit the gut. The presence of the proteins may contribute to the ability of lactic acid bacteria to interact with the host.

The team of scientists found that these mucus-binding proteins also recognise human immunoglobulin proteins. These are an integral part of the immune system. Mucus-binding proteins may therefore also play a wider role in gut health as a site of attachment for bacteria.

"The strain-specificity of these proteins demonstrates the need for the careful molecular design and selection of probiotics," says Dr Juge. "This also opens new avenues of research to study the fundamental roles bacteria play in the gastrointestinal tract."


Story Source:

The above story is based on materials provided by Norwich BioScience Institutes. Note: Materials may be edited for content and length.


Cite This Page:

Norwich BioScience Institutes. "Sticky solution for identifying effective probiotics." ScienceDaily. ScienceDaily, 25 November 2009. <www.sciencedaily.com/releases/2009/11/091124113611.htm>.
Norwich BioScience Institutes. (2009, November 25). Sticky solution for identifying effective probiotics. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/11/091124113611.htm
Norwich BioScience Institutes. "Sticky solution for identifying effective probiotics." ScienceDaily. www.sciencedaily.com/releases/2009/11/091124113611.htm (accessed April 17, 2014).

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