Featured Research

from universities, journals, and other organizations

Mammography may increase breast cancer risk in some high-risk women

Date:
December 3, 2009
Source:
Radiological Society of North America
Summary:
Low-dose radiation from annual mammography screening may increase breast cancer risk in women with genetic or familial predisposition to breast cancer, according to a new study.

Low-dose radiation from annual mammography screening may increase breast cancer risk in women with genetic or familial predisposition to breast cancer, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).

"For women at high risk for breast cancer, screening is very important, but a careful approach should be taken when considering mammography for screening young women, particularly under age 30," said Marijke C. Jansen-van der Weide, Ph.D., epidemiologist in the Department of Epidemiology and Radiology at University Medical Center Groningen in the Netherlands. "Further, repeated exposure to low-dose radiation should be avoided."

Women who are at high risk for breast cancer need to begin screening at a younger age, because they often develop cancer earlier than women at average risk. However, according to Dr. Jansen-van der Weide and colleagues, young women with familial or genetic predisposition to the disease may want to consider alternative screening methods to mammography, because the benefit of early tumor detection in this group of women may be offset by the potential risk of radiation-induced cancer.

According to the American Cancer Society, there is strong evidence supporting the benefits of mammography for women after age 40. However, there are conflicting reports regarding the benefits of mammography for women under 40. Alternative screening methods such as ultrasound and MRI may be made available to younger women, but are generally used as an adjunct to mammography.

The American Cancer Society recommends that some women at high risk (greater than 20 percent lifetime risk) should have MR imaging and mammography every year, typically beginning at age 30.

The researchers conducted an analysis of peer-reviewed, published medical research to determine if low-dose radiation exposure affects breast cancer risk among high-risk women. Out of 47 articles found on the topic, six were selected by the reviewers for inclusion in their analysis. Four studies looked at the effect of exposure to low-dose radiation among breast cancer gene mutation carriers, and two studies researched the effect of radiation on women with a family history of breast cancer. Using data from these studies, the researchers were able to calculate pooled odds ratios to estimate radiation-induced breast cancer risk.

The results showed that among all high-risk women in the study, average increased risk of breast cancer due to low-dose radiation exposure was 1.5 times greater than that of high-risk women not exposed to low-dose radiation. High-risk women exposed before age 20 or with five or more exposures were 2.5 times more likely to develop breast cancer than high-risk women not exposed to low-dose radiation.

"Our findings suggest that low-dose radiation increases breast cancer risk among these young high-risk women, and a careful approach is warranted," Dr. Jansen-van der Weide said.

She noted that this analysis is based on a small study sample and should be interpreted with caution. Dr. Jansen-van der Weide also pointed out that these results apply only to specific high-risk groups of women. Women at average risk were not assessed in this study.

In general, early detection with mammography and prompt treatment can significantly improve a woman's chances of survival. More than 90 percent of women whose breast cancer is found in an early stage will survive. For young, high-risk women and their doctors, it is important to weigh the benefits against any potential risk when making a decision about annual breast cancer screening with mammography.

Coauthors are Geertruida H. de Bock, Ph.D., Marcel J.W. Greuter, Ph.D., Liesbeth Jansen, M.D., Ph.D., Jan C. Oosterwijk, Ph.D., Ruud Pijnappel, M.D., Ph.D., and Matthijs Oudkerk, M.D., Ph.D.


Story Source:

The above story is based on materials provided by Radiological Society of North America. Note: Materials may be edited for content and length.


Cite This Page:

Radiological Society of North America. "Mammography may increase breast cancer risk in some high-risk women." ScienceDaily. ScienceDaily, 3 December 2009. <www.sciencedaily.com/releases/2009/12/091201084059.htm>.
Radiological Society of North America. (2009, December 3). Mammography may increase breast cancer risk in some high-risk women. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2009/12/091201084059.htm
Radiological Society of North America. "Mammography may increase breast cancer risk in some high-risk women." ScienceDaily. www.sciencedaily.com/releases/2009/12/091201084059.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins