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How calorie-restricted diets fight obesity and extend life span

Date:
December 29, 2009
Source:
American Chemical Society
Summary:
Scientists searching for the secrets of how calorie-restricted diets increase longevity are reporting discovery of proteins in the fat cells of human volunteers that change as pounds drop off. The proteins could become markers for monitoring or boosting the effectiveness of calorie-restricted diets -- the only scientifically proven way of extending life span in animals.

Fruits and vegetables are a key part of calorie-restricted diets, which may increase longevity.
Credit: iStockphoto/Jack Puccio

Scientists searching for the secrets of how calorie-restricted diets increase longevity are reporting discovery of proteins in the fat cells of human volunteers that change as pounds drop off. The proteins could become markers for monitoring or boosting the effectiveness of calorie-restricted diets -- the only scientifically proven way of extending life span in animals.

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Their study appears online in ACS' Journal of Proteome Research.

Edwin Mariman and colleagues note that scientists have long known that sharply restricting intake of calories while maintaining good nutrition makes animals live longer and stay healthier. Recent studies suggest that people may gain similar benefits. But scientists know little about how these diets work in humans, particularly their effects on cells that store fat.

The new study focused on proteins in abdominal subcutaneous fat cells from a group of overweight people before and after they went on a five-week-long calorie-restricted diet. The volunteers each lost an average of 21 pounds. Scientists identified changes in the levels of 6 proteins as the volunteers shed pounds, including proteins that tell the body to store fat. These proteins could serve as important markers for improving or tracking the effectiveness of therapies involving calorie-restricted diets, they say.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bouwman et al. The Physiologic Effects of Caloric Restriction Are Reflected in the in Vivo Adipocyte-Enriched Proteome of Overweight/Obese Subjects. Journal of Proteome Research, 2009; 8 (12): 5532 DOI: 10.1021/pr900606m

Cite This Page:

American Chemical Society. "How calorie-restricted diets fight obesity and extend life span." ScienceDaily. ScienceDaily, 29 December 2009. <www.sciencedaily.com/releases/2009/12/091209134642.htm>.
American Chemical Society. (2009, December 29). How calorie-restricted diets fight obesity and extend life span. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2009/12/091209134642.htm
American Chemical Society. "How calorie-restricted diets fight obesity and extend life span." ScienceDaily. www.sciencedaily.com/releases/2009/12/091209134642.htm (accessed April 19, 2015).

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