Featured Research

from universities, journals, and other organizations

More blood vessels in hormone-resistant prostate tumors

Date:
December 16, 2009
Source:
University of Gothenburg
Summary:
Patients with advanced prostate cancer are often treated with hormones, but when the tumors start growing again they have more and different blood vessels, reveals research from Sweden. This discovery paves the way for new treatments for hormone-resistant prostate cancer.

Patients with advanced prostate cancer are often treated with hormones, but when the tumours start growing again they have more and different blood vessels, reveals a thesis from the Sahlgrenska Academy, at the University of Gothenburg, Sweden. This discovery paves the way for new treatments for hormone-resistant prostate cancer.

Related Articles


Late in the course of the disease, when the prostate cancer has spread, most patients are given hormone therapy. This reduces the production of the male sex hormone and the tumour shrinks.

"The problem is that the effect is transient," says molecular biologist Helιne Gustavsson, who wrote the thesis. "Sooner or later the tumour will develop resistance to the hormone treatment and then the cancer will continue to grow, often as secondary tumours in the bones."

Tumours have to make new blood vessels if they are to grow and spread in the body. The thesis shows that the tumours that have relapsed after a patient has been given hormone therapy contain more blood vessels. The blood vessels often also look different to how they looked during the earlier stages of the disease.

Another interesting finding is that levels of a protein known as ADAMTS1 are lower in these aggressive tumours. This protein is known to inhibit the growth of blood vessels. Low levels of the protein in the tumours are associated with more blood vessels and a greater spread of the cancer.

"If we can prevent the tumour from making new blood vessels, we can also prevent the cancer from spreading," says Gustavsson. "Now that we have a better understanding of how the formation of blood vessels is controlled in this stage of prostate cancer, we are in a better position to develop medicines that suppress the formation of new vessels in hormone-resistant prostate cancer."

The research team at the Sahlgrenska Academy will now assess how these changes affect the function of the blood vessels and their sensitivity to different treatments.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "More blood vessels in hormone-resistant prostate tumors." ScienceDaily. ScienceDaily, 16 December 2009. <www.sciencedaily.com/releases/2009/12/091215101712.htm>.
University of Gothenburg. (2009, December 16). More blood vessels in hormone-resistant prostate tumors. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/12/091215101712.htm
University of Gothenburg. "More blood vessels in hormone-resistant prostate tumors." ScienceDaily. www.sciencedaily.com/releases/2009/12/091215101712.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins