Featured Research

from universities, journals, and other organizations

New nasal vaccine blocks parasite transmission to mosquitoes

Date:
December 20, 2009
Source:
American Society for Microbiology
Summary:
An experimental nasally administered malaria vaccine prevented parasite transmission from infected mice to mosquitoes and could play an important role in the fight against human malaria.

An experimental nasally administered malaria vaccine prevented parasite transmission from infected mice to mosquitoes and could play an important role in the fight against human malaria.

Related Articles


Researchers from Japan report their findings in the December 2009 issue of the journal Infection and Immunity.

Malaria is one of the most significant infectious diseases affecting developing countries and is often prominent in children. Mortality and morbidity levels are high and although antimalarial drug chemotherapy and insecticide-treated bed nets have somewhat reduced the number of malaria infections, additional prevention and treatment methods such as vaccines are needed for local elimination and ultimately complete eradication. Prior studies show that the ookinete-to-oocyst phase in the malaria life cycle, when the malarial parasite is fertilized in the mosquito's body, is one of the most vulnerable stages making it an ideal target for antitransmission vaccines.

In the study researchers developed a nasal vaccine based on ookinete-surface proteins (OSPs or also known as parasite antigens) and intranasally vaccinated mice infected with malaria. When given in conjunction with the cholera toxin adjuvant vaccinated mice developed a robust antibody response and completely prevented trasmission of the parasite to mosquitoes that were allowed to feed on them after infection.

"To our knowledge, this is the first time that mucosal vaccination has been demonstrated to be efficacious for directly preventing parasite transmission from vaccinated animals to mosquitoes, and the results may provide important insight into rational design of nonparenteral vaccines for use against human malaria," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Arakawa, M. Tachibana, T. Miyata, T. Harakuni, H. Kohama, Y. Matsumoto, N. Tsuji, H. Hisaeda, A. Stowers, M. Torii, T. Tsuboi. Malaria Ookinete Surface Protein-Based Vaccination via the Intranasal Route Completely Blocks Parasite Transmission in both Passive and Active Vaccination Regimens in a Rodent Model of Malaria Infection. Infection and Immunity, 2009; 77 (12): 5496 DOI: 10.1128/IAI.00640-09

Cite This Page:

American Society for Microbiology. "New nasal vaccine blocks parasite transmission to mosquitoes." ScienceDaily. ScienceDaily, 20 December 2009. <www.sciencedaily.com/releases/2009/12/091219080703.htm>.
American Society for Microbiology. (2009, December 20). New nasal vaccine blocks parasite transmission to mosquitoes. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2009/12/091219080703.htm
American Society for Microbiology. "New nasal vaccine blocks parasite transmission to mosquitoes." ScienceDaily. www.sciencedaily.com/releases/2009/12/091219080703.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins