Featured Research

from universities, journals, and other organizations

Antimicrobial peptide from ancient organism may be effective against multiresistant human pathogens including MRSA

Date:
December 20, 2009
Source:
American Society for Microbiology
Summary:
Researchers in Germany have identified a new antimicrobial peptide that demonstrates significant activity against a variety of bacteria, including multiresistant human strains such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The discovery was made while investigating the ancient metazoan organism Hydra magnipapillata.

Researchers in Germany have identified a new antimicrobial peptide that demonstrates significant activity against a variety of bacteria, including multiresistant human strains such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). The discovery was made while investigating the ancient metazoan organism Hydra magnipapillata.

The researchers from Christian-Albrechts-University and the University Medical Center Schleswig-Holstein Campus, Kiel, Germany report their findings in the December 2009 issue of the journal Antimicrobial Agents and Chemotherapy.

While occurrences of multidrug-resistant infections continue to increase, the discovery and development of drugs effective against these bacterial strains have slowed. Once commonly thought of as a hospital-acquired infection, MRSA has now spread to the community (now known as community acquired or CA-MRSA) and is infecting previously healthy young people who have not been recently hospitalized or undergone a medical procedure. Past research has proven that ancient organisms are well equipped at preventing infectious pathogens from entering the body and given the desperate need for new drug targets, further exploration of these organisms is warranted.

MRSA has already developed resistance to CA-MRSA human antimicrobial peptides and prior studies have shown antibacterial immune responses in the simple metazoan Hydra magnipapillata to include bactericidal peptides with novel structural features and modes of action. In the study researchers identified the antimicrobial peptide arminin 1a from Hydra and found that it exhibited significant and wide-spread activity against bacteria including MRSA and enterococci, a common cause of nosocomial infections that is also drug-resistant. Further observations revealed that bacteria are killed when the bacterial cell wall is disrupted and the antibacterial activity of arminin 1a isn't affected by exposure to salt in human blood. Finally, researchers determined that arminin 1a doesn't share any ancestry with any known antimicrobial peptides.

"Our data suggest that ancient metazoan organisms such as Hydra hold promise for the detection of novel antimicrobial molecules and the treatment of infections caused by the multiresistant bacteria," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Augustin, F. Anton-Erxleben, S. Jungnickel, G. Hemmrich, B. Spudy, R. Podschun, T.C.G. Bosch. Activity of the Novel Peptide Arminin against Multiresistant Human Pathogens Shows the Considerable Potential of Phylogenetically Ancient Organisms as Drug Sources. Antimicrobial Agents and Chemotherapy, 2009; 53 (12): 5245 DOI: 10.1128/AAC.00826-09

Cite This Page:

American Society for Microbiology. "Antimicrobial peptide from ancient organism may be effective against multiresistant human pathogens including MRSA." ScienceDaily. ScienceDaily, 20 December 2009. <www.sciencedaily.com/releases/2009/12/091219080731.htm>.
American Society for Microbiology. (2009, December 20). Antimicrobial peptide from ancient organism may be effective against multiresistant human pathogens including MRSA. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2009/12/091219080731.htm
American Society for Microbiology. "Antimicrobial peptide from ancient organism may be effective against multiresistant human pathogens including MRSA." ScienceDaily. www.sciencedaily.com/releases/2009/12/091219080731.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins