Featured Research

from universities, journals, and other organizations

Urinary tract cancer associated with Chinese herbal products containing aristolochic acid

Date:
December 22, 2009
Source:
Journal of the National Cancer Institute
Summary:
The carcinogen aristolochic acid, which was found in many prescribed Chinese herbal products including Guan Mu Tong, is associated with an increased risk of urinary tract cancer, according to a new study.

The carcinogen aristolochic acid, which was found in many prescribed Chinese herbal products including Guan Mu Tong, is associated with an increased risk of urinary tract cancer, according to a new study published online December 21 in the Journal of the National Cancer Institute.

Many countries, such as Taiwan, have banned products containing aristolochic acid (Taiwan did in 2003), because of clinical cases of urothelial cancer in association with aristolochic acid use. However, no such associations, to the authors' knowledge, have been documented in herbal products containing aristolochic acid.

To examine this association, Jung-Der Wang, M.D., ScD, of the Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, at the National Taiwan University, and colleagues conducted a population-based case-control study of Taiwanese patients newly diagnosed with urinary tract cancer from January 1, 2001, to December 31, 2002. They also looked at a random sample of the entire insured population from January 1, 1997, to December 31, 2002. There were 4,594 case patients and 174,701 control subjects in the final analysis. The authors examined the association between having been prescribed Mu Tong, an herb that contains aristolochic acid, and urinary tract cancer using data from the National Health Insurance reimbursement database.

Having been prescribed more than 60 g of Mu Tong (possibly adulterated by Guan Mu Tong before banned), or consumption of an estimated amount of more than 150 mg of aristolochic acid was associated with an increased risk of urinary tract cancer in a dose-dependent manner. The increased risk was independent of arsenic exposure (another risk factor for urinary tract cancer).

"In addition to a ban on products that contain any amount of aristolochic acid, we also recommend continued surveillance of herbs or Chinese herbal products that might be adulterated with aristolochic acid-containing herbs," the authors write. "Finally, patients with a history of aristolochic acid nephropathy or consumption of Mu Tong or Fangchi before they were banned should be monitored regularly for urinary cancer."

Study limitations: Not all of the diagnoses were confirmed by histopathology reports. Subjects may have taken additional nephrotoxic herbs or agents that were not prescribed. Actual intakes of the prescribed herbal products recorded in the National Health Insurance reimbursement database were not validated. Smoking history was not taken into account.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Urinary tract cancer associated with Chinese herbal products containing aristolochic acid." ScienceDaily. ScienceDaily, 22 December 2009. <www.sciencedaily.com/releases/2009/12/091221212734.htm>.
Journal of the National Cancer Institute. (2009, December 22). Urinary tract cancer associated with Chinese herbal products containing aristolochic acid. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2009/12/091221212734.htm
Journal of the National Cancer Institute. "Urinary tract cancer associated with Chinese herbal products containing aristolochic acid." ScienceDaily. www.sciencedaily.com/releases/2009/12/091221212734.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins