Featured Research

from universities, journals, and other organizations

Heart transplant patients appear to have elevated risk for multiple skin cancers

Date:
December 24, 2009
Source:
JAMA and Archives Journals
Summary:
Many heart transplant patients develop multiple skin cancers, with increased risk for some skin cancers among patients with other cancers and with increasing age, according to a new study.

Many heart transplant patients develop multiple skin cancers, with increased risk for some skin cancers among patients with other cancers and with increasing age, according to a report in the December issue of Archives of Dermatology, one of the JAMA/Archives journals.

"Solid organ transplant recipients are at increased risk for skin cancers," the authors write as background information in the article. "Incidence, tumor burden and risk factors for skin cancer are well documented in renal transplant recipients. However, these characteristics are documented to a lesser extent in heart transplant patients, who are at least twice as likely to have skin cancer compared with renal transplant recipients." Reasons for this could include the greater use of immunosuppressive medications and an older average age at the time of transplant.

Jerry D. Brewer, M.D., of Mayo Clinic, Rochester, Minn., and colleagues reviewed the records of 312 patients who had received heart transplants between 1988 and 2006. Patients had an average age of 47.4 years at the time of their transplant and information was extracted from their charts regarding overall characteristics, cancers, risk factors and death.

The patients developed a total of 1,395 skin cancers; overall, 46.4 percent of the patients had developed skin cancer during the 19 years of follow-up. This included 1,236 squamous cell carcinomas and 151 basal cell carcinomas (the non-melanoma skin cancers), five malignant melanomas and three other types.

When evaluating the tumor burden of the 312 patients, 76 (24.4 percent) had at least one squamous cell carcinoma, 24 (7.7 percent) had only one squamous cell carcinoma and 19 (6.1 percent) had 10 or more; in addition, 54 (17.3 percent) had at least one basal cell carcinoma, 23 (7.4 percent) had only one and two (0.6 percent) had 10 or more.

Patients were more likely to develop squamous cell carcinoma if they had other types of cancer after their transplant, were older or had a known cause for their heart failure. Infection with the herpes simplex virus, being older and using a medication known as mycophenolate to suppress the immune system were associated with an increased risk of basal cell carcinoma.

"Although a considerable tumor burden was found in this study, the rate of death due to skin cancer was surprisingly low. Only one patient died of skin cancer, of a melanoma," the authors write. "Health care providers and patients at our center have been educated for more than 10 years about the risk, early detection and treatment of skin cancer, which is apparent from the low mortality rate seen in the patients of this study."

"Vigilant sun protection practices, skin cancer education, regular skin examinations and daily vitamin D supplementation are appropriate interventions in these high-risk heart transplant patients," they conclude.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jerry D. Brewer; Oscar R. Colegio; P. Kim Phillips; Randall K. Roenigk; M. Amanda Jacobs; Diederik Van de Beek; Ross A. Dierkhising; Walter K. Kremers; Christopher G. A. McGregor; Clark C. Otley. Incidence of and Risk Factors for Skin Cancer After Heart Transplant. Arch Dermatol, 2009; 145 (12): 1391-1396 [link]

Cite This Page:

JAMA and Archives Journals. "Heart transplant patients appear to have elevated risk for multiple skin cancers." ScienceDaily. ScienceDaily, 24 December 2009. <www.sciencedaily.com/releases/2009/12/091221212750.htm>.
JAMA and Archives Journals. (2009, December 24). Heart transplant patients appear to have elevated risk for multiple skin cancers. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2009/12/091221212750.htm
JAMA and Archives Journals. "Heart transplant patients appear to have elevated risk for multiple skin cancers." ScienceDaily. www.sciencedaily.com/releases/2009/12/091221212750.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins