Featured Research

from universities, journals, and other organizations

Licorice root: Trip to the candy store might help ward off rare, but deadly infections

Date:
January 4, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
As it turns out, children were not the only ones with visions of sugar plums dancing in their heads over this past holiday season. In a new study, scientists show how a compound from licorice root might be an effective tool in battling life-threatening, antibiotic-resistant infections resulting from severe burns.

Natural licorice root.
Credit: iStockphoto/Elena Ray

As it turns out, children were not the only ones with visions of sugar plums dancing in their heads over this past holiday season. In a new research report published in the January 2010 issue of the Journal of Leukocyte Biology, a team of scientists from the University of Texas Medical Branch and Shriners Hospitals for Children shows how a compound from licorice root (glycyrrhizin from Glycyrrhiza glabra) might be an effective tool in battling life-threatening, antibiotic-resistant infections resulting from severe burns.

Related Articles


Specifically, they found that in burned mice, glycyrrhizin improved the ability of damaged skin to create small proteins that serve as the first line of defense against infection. These proteins, called antimicrobial peptides, work by puncturing the cell membranes of bacteria similar to how pins pop balloons.

"It is our hope that the medicinal uses of glycyrrhizin will lead to lower death rates associated with infection in burn patients," said Fujio Suzuki, Ph.D., one of the researchers involved in the work. Suzuki also said that more research is necessary to determine if this finding would have any implications for people with cystic fibrosis, who can develop Pseudomonas aeruginosa infections in their lungs.

To make this discovery, Suzuki and colleagues used three groups of mice. The first group was normal, the second group was burned and untreated, and the third group was burned and treated with glycyrrhizin. The skin of the untreated burned mice did not have any detectable antimicrobial peptides that prevent bacteria from growing and spreading, but the normal mice did. The skin of the untreated burned mice also had immature myeloid cells, which indicate an inability of the skin to produce antimicrobial peptides needed to prevent infection. The mice treated with glycyrrhizin, however, were more like the normal mice as they had the antimicrobial peptides and no immature myeloid cells.

"Burns are the most painful of all injuries," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology, "and the deadly Pseudomonas infections that can result from severe burns do more than add insult to those injuries. This research should serve as an important stepping stone toward helping develop new drugs that help prevent or treat Pseudomonas."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tsuyoshi Yoshida, Shohei Yoshida, Makiko Kobayashi, David N. Herndon, and Fujio Suzuki. Glycyrrhizin restores the impaired production of β-defensins in tissues surrounding the burn area and improves the resistance of burn mice to Pseudomonas aeruginosa wound infection. Journal of Leukocyte Biology, 2010; 87: 35-41 [link]

Cite This Page:

Federation of American Societies for Experimental Biology. "Licorice root: Trip to the candy store might help ward off rare, but deadly infections." ScienceDaily. ScienceDaily, 4 January 2010. <www.sciencedaily.com/releases/2010/01/100104101215.htm>.
Federation of American Societies for Experimental Biology. (2010, January 4). Licorice root: Trip to the candy store might help ward off rare, but deadly infections. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2010/01/100104101215.htm
Federation of American Societies for Experimental Biology. "Licorice root: Trip to the candy store might help ward off rare, but deadly infections." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104101215.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Amazon Keeps Its Green Thanks To The Sahara Desert

The Amazon Keeps Its Green Thanks To The Sahara Desert

Newsy (Feb. 25, 2015) Satellite data shows the Amazon rainforest supports its lush flora with a little help from Sahara Desert dust. Video provided by Newsy
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Marijuana Nowhere Near As Deadly As Alcohol: Study

Marijuana Nowhere Near As Deadly As Alcohol: Study

Newsy (Feb. 25, 2015) A new study says marijuana is about 114 times less deadly than alcohol. Video provided by Newsy
Powered by NewsLook.com
Fox With Horrifying Injury Rescued and Released Back Into the Wild

Fox With Horrifying Injury Rescued and Released Back Into the Wild

RightThisMinute (Feb. 25, 2015) This wounded fox knew what she was doing when she wandered into the yard of a nature photographer. The photographer got "Scamp" immediately in the hands of Wildlife Aid and she was released back into the wild in no time. Video provided by RightThisMinute
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins