Featured Research

from universities, journals, and other organizations

Dampening CD4+ immune cell function via the protein TLR4

Date:
January 4, 2010
Source:
Journal of Clinical Investigation
Summary:
The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages has been well characterized, but the role of TLR4 on immune cells known as CD4+ T cells has not been determined.

The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages has been well characterized, but the role of TLR4 on immune cells known as CD4+ T cells has not been determined.

Related Articles


However, José M. González-Navajas, Eyal Raz and colleagues, at the University of California at San Diego, La Jolla, have now determined that triggering TLR4 on CD4+ T cells dampens their inflammatory function, as TLR4 deficiency in two mouse models of colitis (inflammation of the intestines) accelerated the development of disease and/or induced more severe disease.

Further analysis identified a molecular signaling pathway underlying the inhibitory effects of TLR4 triggering on CD4+ T cell inflammatory function, providing insight into the regulation of CD4+ T cell responses.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. José M. González-Navajas, Sean Fine, Jason Law, Sandip K. Datta, Kim P. Nguyen, Mandy Yu, Maripat Corr, Kyoko Katakura, Lars Eckman, Jongdae Lee and Eyal Raz. TLR4 signaling in effector CD4 T cells regulates TCR activation and experimental colitis in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40055

Cite This Page:

Journal of Clinical Investigation. "Dampening CD4+ immune cell function via the protein TLR4." ScienceDaily. ScienceDaily, 4 January 2010. <www.sciencedaily.com/releases/2010/01/100104210625.htm>.
Journal of Clinical Investigation. (2010, January 4). Dampening CD4+ immune cell function via the protein TLR4. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2010/01/100104210625.htm
Journal of Clinical Investigation. "Dampening CD4+ immune cell function via the protein TLR4." ScienceDaily. www.sciencedaily.com/releases/2010/01/100104210625.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins