Featured Research

from universities, journals, and other organizations

Imaging studies help detect underlying cancers in patients with neurologic symptoms

Date:
January 12, 2010
Source:
JAMA and Archives Journals
Summary:
A combined positron emission tomography-computed tomography (PET-CT) scan of the whole body appears to detect cancer in individuals with related neurologic complications more accurately than some other commonly used tests, according to new report.

A combined positron emission tomography-computed tomography (PET-CT) scan of the whole body appears to detect cancer in individuals with related neurologic complications more accurately than some other commonly used tests, according to a report posted online that will appear in the March print issue of Archives of Neurology, one of the JAMA/Archives journals.

Paraneoplastic neurologic disorders occur in some people with cancer -- including lung, breast or ovarian cancer -- and may develop when cancer-fighting antibodies mistakenly attack cells in the nervous system. "In the assessment of patients with suspected paraneoplastic neurologic disorders, routine non-invasive oncologic evaluations may be unrevealing," the authors write as background information in the article. "These standard evaluations include physical examination; computed tomography (CT) of the chest, abdomen and pelvis; mammography in women; and testicular ultrasonography and prostate-specific antigen testing in men." Cancers underlying paraneoplastic neurologic disorders are typically small, restricted to one site and are often not detected until autopsy.

Andrew McKeon, M.B., M.R.C.P.I., and colleagues at Mayo Clinic, Rochester, Minn., analyzed the medical records of 56 consecutive patients with suspected paraneoplastic neurologic disorders whose standard evaluations (including CT) did not reveal cancer. All of them underwent PET-CT at Mayo Clinic between 2005 and 2008.

PET-CT detected abnormalities suggestive of cancer in 22 of the patients (39 percent), of whom 10 (18 percent) had cancer diagnoses confirmed by biopsy or another method. Of these cancers, two were in the thyroid, one was in the tonsil, three were in the lungs, one was in the colon and three were cancerous lymph nodes with unknown primary cancer sites. Nine of the ten were early-stage cancers, and detection facilitated early treatment. Cancer remission was reported in seven patients and improvement in neurologic symptoms in five patients after a median (midpoint) of 11 months of follow-up.

Before their PET-CT, patients underwent a median of three other screening tests; the most common was CT of the chest, abdomen and pelvis. "However, four of the 10 detected cancers using PET-CT were outside the anatomical scope of CT of the chest, abdomen and pelvis (thyroid, two; cervical lymph node, one; and palatine tonsil, one)," the authors write. "The other six detected cancers were too small to be detected by appropriate regional CT (lung, four; axillary lymph node, one; and colon, one). Clearly, CT alone is not sufficient to exclude cancer in cases with a high index of suspicion for cancer."

Some types of cancer, including bladder and kidney cancers, are more difficult to detect by PET-CT, the authors note. "Recognizing the limitations of PET-CT, we favor this modality for initial oncologic evaluation of patients in whom a paraneoplastic neurologic disorder is strongly suspected," they conclude. "Elimination of whole-body imaging with CT alone before further imaging with PET-CT could reduce radiation exposure and the total financial burden of testing."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrew McKeon; Metha Apiwattanakul; Daniel H. Lachance; Vanda A. Lennon; Jayawant N. Mandrekar; Bradley F. Boeve; Brian Mullan; Bahram Mokri; Jeffrey W. Britton; Daniel A. Drubach; Sean J. Pittock. Positron Emission Tomography- Computed Tomography in Paraneoplastic Neurologic Disorders: Systematic Analysis and Review. Arch Neurol, 2010; 0 (2010): 2009. 336 [link]

Cite This Page:

JAMA and Archives Journals. "Imaging studies help detect underlying cancers in patients with neurologic symptoms." ScienceDaily. ScienceDaily, 12 January 2010. <www.sciencedaily.com/releases/2010/01/100111161933.htm>.
JAMA and Archives Journals. (2010, January 12). Imaging studies help detect underlying cancers in patients with neurologic symptoms. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2010/01/100111161933.htm
JAMA and Archives Journals. "Imaging studies help detect underlying cancers in patients with neurologic symptoms." ScienceDaily. www.sciencedaily.com/releases/2010/01/100111161933.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins